mfn2基因促进血管平滑肌源性泡沫细胞胆固醇外排机制研究

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1、分类号学号D200978319学校代码10487密级博士学位论文博士学位论文博士学位论文博士学位论文Mfn2基因促进血管平滑肌源性泡沫细胞胆固醇外排机制研究学位申请人：贺超学科专业：内科学指导教师：郭小梅教授答辩日期：2013年4月AdissertationsubmittedtoHuazhongUniversityofScienceandTechnologyfortheDegreeofDoctorofMedicineThemechanismofMfn2Genetopromotecholesteroleffluxinvascularsmoothmusclecell-derivedfo

2、amcellsD.Candidate:HeChaoMajor:Int.Med.(Cardiology)Supervisor:Prof.XiaomeiGuoHuazhongUniversityofScience&TechnologyWuhan430074,P.R.ChinaApril,2013独创性声明本人郑重声明，本学位论文是本人在导师指导下进行的研究工作及取得的研究成果的总结。尽我所知，除文中已经标明引用的内容外，本论文不包含任何其他个人或集体已经发表或撰写过的研究成果。对本文的研究做出贡献的个人和集体，均已在文中以明确方式标明。本人完全意识到本人将承担本声明引起的一切法律后果。

3、学位论文作者签名：日期：年月日学位论文版权使用授权书本学位论文作者完全了解学校有关保留、使用学位论文的规定，即：学校有权保留并向国家有关部门或机构送交论文的复印件和电子版，允许论文被查阅和借阅。本人授权华中科技大学可以将本学位论文的全部或部分内容编入有关数据库进行检索，可以采用影印、缩印或扫描等复制手段保存和汇编本学位论文。保密□，在_____年解密后适用本授权书。本论文属于不保密□。（请在以上方框内打“√”）学位论文作者签名：指导教师签名：日期：年月日日期：年月日目录一、缩略语表···················································

4、··························1二、中文摘要·············································································4三、英文摘要·············································································6四、正文····················································································9前言········

5、··········································································9第一部分外源性Mfn2基因表达抑制平滑肌源性泡沫细胞形成···16第二部分外源性Mfn2基因对泡沫细胞形成丝裂原活化蛋白激酶信号通路的影响····································································44五、综述············································································

6、····52泡沫细胞胆固醇转运分子机制研究进展································52六、致谢················································································76华中科技大学博士学位论文缩略语表adenosinetriphosphate-bindingcassette三磷酸腺苷结合盒转运体ABCA1subfamilyAmember1A1adenosinetriphosphate-bindingcassette三磷酸腺苷结合盒转运体ABCG1subfamilyG

7、member1G1Advadenovirus腺病毒APammoniumpersulphte过硫酸铵apoAIapolipoproteinA载脂蛋白ADMSOdimethylsulfoxide二甲基亚砜EDTAethylenediaminetetraaceticacid乙二胺四乙酸ELISAenzyme-linkedimmunosorbentassay酶联免疫吸附法ERK1/2extracelluarsignal-relatedkinase1/2细胞外信号调节激酶1/2