非t细胞结合肽对类风湿关节炎的治疗作用及免疫学机制探讨

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1、河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组)的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学，试验材料、原始数据、申报的专否则，承担相应法律责任。研究生签名：糯泵导师签章河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：缪薏袭

2、导师签章：矽f中目录中文摘要⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．1英文摘要⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．4英文缩写⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．8研究论文非T细胞结合肽对类风湿关节炎的治疗作用及免疫学机制探讨弓l言··········”···．······．······．··．·．．···．．．．··．．．．．”．．．．．“．．．．．．．．．．．9第一部分非T细胞结合肽对类风湿关节炎的治疗作用前言．．⋯．．．．．．．．．．．．．．．．⋯．．．．．．．．．．．．⋯．⋯．．．．．．．．．．．．．．．．．．．．．．．．．．．10刖舌一一“·”“·

3、·”一···”一一”““””““”一··”·“·····一·”·“······10材料与方法⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．·10结果···⋯···⋯···········⋯··············⋯········⋯················13附图···································································．．·15附表···································”·······························．·20讨论··············

4、························································22结j沧··．····················⋯DDBD······································．·23参考文献⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯·24第二部分非T细胞结合肽对CIA大鼠效应T细胞分型的影响前言⋯．．．．．．。．．．．．．．．．．．。。．．．．。。．．．．。。．．．．．．。。．⋯．．⋯．。。⋯．．．．⋯．。．。。26再U吾⋯·······································。‘⋯·

5、·⋯。··⋯‘‘··⋯·····26材料与方法⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯·．26结果···························⋯··········⋯············⋯······⋯⋯30附图··一····一··············“····“··．．·一······················IQOL10·····31附表⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯·36讨论·．．·······························································．．．·39结论．．．····．．．·

6、····．···．．．．··．．．．·····．．························．．···．．．．．40参考文献⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．41／J＼结···················一·····”·············一········．．············“······”43综述MAPK信号转导通路与类风湿关节炎的研究进展⋯⋯⋯⋯⋯44致谢···························．·····．．···················．···．．·····．．．·．．．．．．53个人简历⋯⋯··DDD⋯⋯⋯⋯⋯⋯⋯⋯··I

7、DDDIIDIO⋯⋯⋯⋯⋯⋯⋯．54中文摘要非T细胞结合肽对类风湿关节炎的治疗作用及免疫学机制探讨摘要类风湿关节炎(rheumatoidarthritis，RA)是一种慢性、进展性、自身免疫性疾病，以炎性细胞在关节滑膜处浸润，滑膜增生，血管翳形成，关节软骨及骨的持续破坏为特征。由于RA病因未明，缺乏根本治疗药物，故成为世界性治疗难题。因此探索RA的病理生理过程，研究治疗RA的药物越来越受到重视。非T细胞结合肽(NTAP)是处于研发阶