非t细胞结合肽对胶原诱导关节炎大鼠的治疗作用及其机制研究

《非t细胞结合肽对胶原诱导关节炎大鼠的治疗作用及其机制研究》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组)的指导下，由本人独立完成。本学位论文研究所获的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名单位为河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相应的法律责任。，v．。_。、，7．研究生签名：京两导师签章：签章：月2j雕，，i～～一}一’．J’研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注等内容外，

2、文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：李曩导师签章：岁日彰唧乏仪阵巍卅目录lIllIlUllIllIIIIIIIlY2583435中文摘要⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．．1英文摘要⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．5英文缩写⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯···⋯⋯⋯⋯⋯⋯．10研究论文非T细胞结合肽对胶原诱导关节炎大鼠的治疗作用及其机制研究弓l言··················································

3、··········．········．11第一部分非T细胞结合肽对胶原诱导关节炎大鼠的治疗作用前言·························．．···············．·················．········．13日Ⅱ茜·················································”···················13材料与方法⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．．13结果··················································

4、···················．17I村图·························．．．．·············．．········．·······．·······．．19附表···”“···”····”·”····”．．··“-”··”··．·．一”······””””·····．-24讨论·····”··················．．···············．．．························．26d、结“························．·．．········．···．．··

5、··············．·······．．28参考文献⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．29第二部分非T细胞结合肽对胶原诱导关节炎大鼠辅助性T细胞亚群的影响前言·····⋯．．．．．．．·．·．．．．．．．．．．．．．·．．．．．．．．．．．．．·．．．．·．．．．．．．．．．．．．．-．．．．32翮吞·····“···························“·····························-····32材料与方法⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．．33结果-···············

6、·········．．．．．·············．．······················．·．39I咐图···························．·．············．．．···············．······．．．40I村表·······．·．．．．．··．．．．··．．·．．．．．．···．·．．．．·．．．．．·····．．．．．．．·．．．····．．．．51讨论··························．．．．············．．．·········．·····．·····．．．

7、．54／J、结·······”·””·””···“·．．··“···········．．·······”·“····．·“··．．．．56参考文献⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．57第三部分非T细胞结合肽对胶原诱导关节炎大鼠滑膜组织和脾脏T淋巴细胞凋亡的影响前言·························．．．．．···．．．．．．．··．．．······．．．．．．．．．．．·．．·．．．．59翮舌··································································

8、····59材料与方法⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．-59结果························