乳腺癌空芯针穿刺与开放切除活检前后循环肿瘤细胞变化的初步分析

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1、第三军医大学硕士学位论文Methods&ResultsPartI．Theclinicalapplicationofcoreneedlebiopsy(CNB)indiagnosisofmastopathywithoutobviousmass．Methods：Frommay，201toDec，2011,891patientswereenrolledinthestudy：1)withbreastpainandmass(asymmetricalmassorpatchyglandsthickeninginunilateral

2、breast)，2)BI-RADS0-3，3)noimprovementwasfoundaftertreatmentwithTamoxifenorChineseformulatedproducts．TheyallacceptedCNB．Theclinicalmanifestationinpalpationandhistopathologicchangeswereinvestigated，andpatientsdiagnosedwithatypicalhyperplasiawerefollowedup．Results

3、891patientshadCNBcheck，5patientswasdiagnosedasinvasiveductalcarcinoma，6patientswasintraductalcarcinoma，1patientwasmalignantlymphoma，35patientswereatypicalductalhyperplasia，andtherestwasadenosisofbreast．Amongthese35patientswithatypicalductalhyperplasia，22patien

4、tsacceptedoperation．11casewerediagnosedasinvasiveductalcarcinoma，5patientswasintroductalcarcinomaand6patientswasadenosisandatypicalductalhyperplasia．7patientsrefusedoperationandremainedinthefollowingup．PartIITheclinicalapplicationofER，PR，HER-2andWTlexpressesin

5、thegeneratinganddevelopmentofbreastcancerMethods：Therewere95specimensthathadconfirmeddiagnosedbypathology．[22casesofepitheliahyperplasia，23ofepitheliaatypicalhyperplasia(ADH)，23ofductalcarcinomainsitu(DCIS)，27ofDCISwithmicroinvasivelesions]，Histopathologyisgot

6、todetecttheexpressionsofER，PR，HER一2andWT1intheepitheliahyperplasia，ADH，DCISandDCISwithmicroinvasivelesions，andtoinvestigatetheirvariationandthepossiblemechanisminthegeneratinganddevelopmentofbreastcancer．ResultsThepositiveexpressionratesofERinepitheliahyperpla

7、sia，ADH，DCIS，DCISwithmicroinvasivelesionswere63．6％、73．9％、65．2％and51．9％(p=0．445)．ThepositiveexpressionratesofPRrespectivelyare59．09％、69．57％、60．87％and44．44％(p=O．336)．ItpositiveexpressionlevelsandtrendsarethesamewithER，ItpromptsUSthattheexpressionlevelsofER，PRare

8、increasingintheearlystageofthebreastcancer．ThepositiveexpressionratesarehighestinADH．FormtheprocessofDCIStoDCISwithmicroinvasivelesions，Thepositiveexpressionratesdeclineobviously，b