利塞膦酸钠防治绝经后妇女骨质疏松症的有效性和安全性

《利塞膦酸钠防治绝经后妇女骨质疏松症的有效性和安全性》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、英文摘要Efficacyandsafetyofrisedronatesodiuminpreventionandtreatmentofwomenwithpostmenopausalosteoporosis，aprospectiverandomizedplacebo-controlledtrail：1-yearoftreatmentplus1-yearoffollow-upABSTRACTObjective：Toevaluatetheefficacyandsafetyoforaladministration

2、ofrisedronatesodiuminpreventionandtreatmentofwomenwithpostmenopausalosteoporosis，toprovideevidenceandtheexperiencesforclinicalpractice．Methods：Therewasaprospective，randomized，double—blindandplacebo-controlstudyduration1ye屿andalsoplus1-yearofuntreatedfoll

3、ow—up．68CaseSpostmenopausalwomenwithosteoporosis(n=46)orosteopenia(n=22)wereenrolled，whowererandomizedtoreceiveeitherrisedronate(5mg／d)orplacebofor12months．Allsubjectsweresupplementedwithcalcium600mgandvitaminD3125unitsdailysimultaneously．Allpatientswere

4、followedupat0，1，3，6，9，12and24恤months．Thebonemineraldensity(BMD)oflumbarspine(I吒，L3，L4andL2～4)，hip(femoralneck,trochanter,thetotalofthehipandwards’Sfriangle)andnon·superiorityfocileweredeterminedbydualenergyX-rayabsorptionmetry(DEXA)at0，6，12and24mmonths，a

5、swellasthebonemetabolismmarkersincluding英文摘要serumcalcium，fosfonls，urinaryN—telopeptide(NTX)，boneglaprotein(BGP)andtotalalkalinephosphatase(tALP)weredetected．Routinebloodandurinetest，liverandrenalfunctionsweremeasured，electrocardiographyandthoracicandlumb

6、erspinelateralX-raywereperformedatthesametime．Thesideeffectsandnewlybonefractureswereassessedineverypatient．BMD，bonemetabolismmarkersandadverseeventswerecomparedbeforeandaftertreatmentintwogroups．Result：61caseswomencompletedthestudy．1Tocompareallofthetes

7、tedparametersbeforetreatmentandthedifferencesinthepercentagechangefrombaselinerespectivelyintwogroupsat6”month．1．1ThechangesofBMDoflumbarspine(L2，L3，L4andk～4)inexperimentalgroupwere(3．70-J：1．26)％，(2．93+1．60)％，(2．23：1：1．18)％and(3．13+1．10)％respectively,whi

8、letheirchangesinthecontrolgroupwere(一0．19-士-0．75)％，(0．06-x0．39)％，(0．074-0．42)％and(0．01+0．35)％，P