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ID:33948220
大小:1.81 MB
页数:35页
时间:2019-03-02
《森林脑炎患者血清中基质金属蛋白酶-9水平检测意义的研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、分类号——ICS学校代码!Ql圣鱼学号垫!Q鲤!婴萎I£~菱一§复肉蒙名民燕大学硕士学位论文森林脑炎患者血清中基质金属蛋白酶一9水平检测意义的研究StudiesonTheSignificanceofTheDetectionofMMP·-9levelinTheSerumofPatientswithTick-BorneEncephalitis申请人:学科专业:研究方向:学位类别:指导教师:于慧敏中西医结合临床蒙西医结合内科学学术学位张晓光教授论文提交日期:二O一三年四月摘要I唧嬲目的:通过检测森林脑炎患者急性期和恢复期
2、血清中MMP.9的含量;研究MMP.9与森林脑炎病人病情轻重的相关性;明确MMP.9可否作为森林脑炎病人诊断和判断病情轻重的定量指标。方法:临床确诊的森林脑炎患者90例;按照病情程度分为轻度、中度、重度三组;在发病第1.3天(急性期)初查及第10.15天(恢复期)复查抽血,检测森林脑炎患者血清中的MMP.9的水平,记录及比较急性期和恢复期血清中MMP.9水平的变化;并进一步比较急性期轻、中、重三组森林脑炎患者MMP.9水平有何差异,进行统计学分析。结果:急性期血清MMP.9含量明显高于恢复期,差异有统计学意义(P<
3、0.01或P<0.05);血清中MMP.9可做为早期诊断森林脑炎的指标:急性期重组MMP.9含量明显高于中组和轻组,差异有统计学意义(P<0.01或P4、sAbstractobjecfive:IresearchthecorrelationbetweenMMP.9andforestencephalitispatientsillness妣19htbydetectingtheforestencephalitispatientswiththeacutephaseandconvalescenceserumlevelsofMMP一9AtthesalTletime,IspecifyMMP.9whetherornotaSaforeStenc印halltlspatientsdiagn5、osisandquantitativemeasureofillnessseventy.Methods:Ic011ect9【JcaS船forestencephalitispatients.Theyaredividedintothreegroups:mild,moderateandseve诧·Atthefirstthreedays(1—3dayswecalleditacutephase),Icaul眵ont11epreliminarybloodte8tstothepatients.Fromthetenthdaystot6、hefifteenthdays(10.15davswecalleditr∞.o,veryphase)Icarryonthereviewbloodteststothepatients.MeanwhileItestthetorestencephalitispatientsserumlevelsofMMP一9Inthemeantime,IrecordandcomDaretheacutephaseandconvalescencethechangeofserumlevelofMMP.9,anddo向rthercomparlS7、0nofthedifferenceamongthethreegroupsofforestencephalitispatientsabouttheirleVelofMMP-9·Ifinallymakeastatisticalanalysisinviewoftheabovesituation.ResuIts:l:heacutephaseserumcontentofMMP一9isapparentlyhigherthantherecovervcontentofMMP_9.Statisticalanalysisshowsth8、atthedifferencewassignificant(P
4、sAbstractobjecfive:IresearchthecorrelationbetweenMMP.9andforestencephalitispatientsillness妣19htbydetectingtheforestencephalitispatientswiththeacutephaseandconvalescenceserumlevelsofMMP一9AtthesalTletime,IspecifyMMP.9whetherornotaSaforeStenc印halltlspatientsdiagn
5、osisandquantitativemeasureofillnessseventy.Methods:Ic011ect9【JcaS船forestencephalitispatients.Theyaredividedintothreegroups:mild,moderateandseve诧·Atthefirstthreedays(1—3dayswecalleditacutephase),Icaul眵ont11epreliminarybloodte8tstothepatients.Fromthetenthdaystot
6、hefifteenthdays(10.15davswecalleditr∞.o,veryphase)Icarryonthereviewbloodteststothepatients.MeanwhileItestthetorestencephalitispatientsserumlevelsofMMP一9Inthemeantime,IrecordandcomDaretheacutephaseandconvalescencethechangeofserumlevelofMMP.9,anddo向rthercomparlS
7、0nofthedifferenceamongthethreegroupsofforestencephalitispatientsabouttheirleVelofMMP-9·Ifinallymakeastatisticalanalysisinviewoftheabovesituation.ResuIts:l:heacutephaseserumcontentofMMP一9isapparentlyhigherthantherecovervcontentofMMP_9.Statisticalanalysisshowsth
8、atthedifferencewassignificant(P
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