165例ⅰa1-ⅱa2期子宫颈腺癌的临床病理特征与预后相关因素分析

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1、万方数据浙江大学硕士学位论文英文摘要Clinicopathologiccharacteristicsandprognosticfactorsof165casesofIal-lla2stageadenocarcinomaoftheuterinecervixSchoolofMedicine，Specialty,ILqw-PostgraduateSupervisorZhejiangUniversityObstetricsandGynecologyWencaiTianYaxiaChenAbstractobjectiv

2、eAnalysetheclinicopathologiccharacteristicsandprognosticfactorsof165casesofIa1．IIa2stageadenocarcimaoftheuterinecervix(AC)．Methods165casesofcervicaladenocarcinomathatundergoneradicalhysterectomywerediagnosedinZhejiangUniversityWomen’Shospitalfrom2003．06to20

3、13．06．Characteristicsinclugingage，firsttimesexage，numbersofpregnancy，histologicaltype，Rlnlormarkers，gradeofdifferentiation,biggestlineofturnor，resectionmargin，lymph-vascularspaceinvasion(LVSI)，lymphnodemetastasis，parametriuminvasion(PI)，ovarianmetastasis，ne

4、oadjuvantchemotherapy(NACT)，postoperativeadjuvanttherapy,stateofrecurrenceandsurvivalwerecollected．Thenweinvestigatedtheprobableprognosticfactorsbythemeansofuniviariateandmultivariateanalysis．ResuitThe5-yearoverallsurvival(OS)and5一yearrecurrence—freesurviva

5、lrate(RFS)were89．5％，88．9％respectively．Age，stage，gradeofdifferentiation，lymphnodeIV万方数据浙江大学硕士学位论文英文摘要metastasis，deepstromalinfiltration,ovarianmetastasisandpostoperativeadjuvanttherapyweresignificantforRFSinuniviariateanalysis．ForOS，gradeofdifferentiation，ly

6、mphnodemetastasis，deepstromalinfiltration，ovarianmetastasisandpostoperativeadjuvanttherapyweresignificant．MultiviariateanalysisimpliedthatovarianmetastasisandpostoperativeadjuvanttherapywerecommonprognosticfactorsforOSandDFS，gradeofdifferentiationWaSallanot

7、herprognosticfaotorforRFS．ConclusionRROvarianmetastasis，postoperativeadjuvanttherapyandgradeofdifferentiationweresignicantforRFS．BothovarianmetastasisandpostoperativeadjuvanttherapyaffectedOSforIal—IIa2stagecervicaladenocarcinoma．Radicalhysteractermywastheo

8、ptimaltreatmentforearlystageadenocarcinomaoftheuterinecervix．Ovarianpreservationwasfeasibleduringtheoperation．砀ebetterpostoperativetreatmentWasradiotherapyforthecervicaladenocarcinomawihhighriskfactors