2型糖尿病骨质疏松相关性分析

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1、英文摘要Correlationstudyoftype2diabeticosteoporosisABSTRACTobjective：Osteoporosis(OP)isasystemicskeletaldisordercharacterizedbylowbonemassandmicro-architecturaldeteriorationofbonetissue，withaconsequentincreaseinbonefragilityandSusceptibilitytofracture．Therecen

2、tyearshaveseenthequickdevelopmentofindustry,agingpopulationandprolongedlifespan，theprevalenceofosteoporosisisincreasing．Nowadays，BMDwasmeasuredbythedualenergyx-rayabsorptiometry(DEXA)scan．Therearevariousfactorsassociatedwithosteoporosisandosteopenia．Diabet

3、icosteoporosisisoneofthebonediseasecomplications．111erelationbetweenty’pe2diabetesmellitusandosteoporosishasn’tbeenfiguredoutyetandallkindsofbonemasschangeshavebeenreported．Inordertoimposeappropriateinterventiontohighriskpatients，wefocusontherelationbetwee

4、nseveralfactorsandbonemineraldensity(BMD)intype2diabetesmellitus，suchasage，gender,bodymassindex(BMI)，bodysurfacearea(BS)andosteoporosisself-assessmenttoolforAsians(OSTA)index．AlldiabeticpatientsandnormalpeoplehadBMDmeasurementoffemurareaandthelumbarspine．T

5、hedatawasenteredinthedatabasetoanalysistheeffectfactorsofbonemineraldensityanddiabeticeffectonbonemetabolism．Methods：Atotalof396outpatientsandinpatientswereincludedinTheThirdHospitalofHebeiMedicalUniversityfromFeb．201toFeb2012．Thereare191type2diabeticpatie

6、nts(groupDM)including51maleand140female，while205healthypeople(groupNC)including61maleand144female．AllsubjectsweremeasuredBMDatL2．L4lumbarvertebrae，bothfemurs(neck，greattrochanter，intertrochanterandtotal)byDEXA．Clinicalparameters：gender、age、heightandweightw

7、ererecorded，BMI、BSandOSTAindexwerecalculated．Results：‘l英文摘要1ThecomparisonofallsitesBMDbetweenDMandNCgroupNostatisticaldifferenceofBMDatL2andL3betweenDMgroupandNCgroup；TherewasstatisticaldifferenceofBMDatL4，L2—4andfemurbetweenDMgroupandNCgroup．2Themultivari

8、ateregressionanalysisbetweenBMDandgender，age、BMI、BS、OSTAindexindiabeticgroupandcontrolgroup2．1InDMgroup?L2、L3、L2一L4、Rtotal、LfemurBMDwerepositivelycorrelatedwithBMIandBS，negativelycorrelatedwithageandOSTAindex