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ID:33750276
大小:1.10 MB
页数:33页
时间:2019-02-28
《神经电生理技术在糖尿病小纤维神经病变的诊断应用》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、南昌大学硕士学位论文神经电生理技术在糖尿病小纤维神经病变的诊断应用姓名:王祥云申请学位级别:硕士专业:神经病学指导教师:王春芝201205摘要目的:探讨神经电生理检测技术在糖尿病周围神经病变的诊断应用,特别是定量温度阈值检i9ltJ(QTT)在糖尿病小纤维神经病变的诊断应用。方法:对120例糖尿病患者分别进行定量温度阈值检测(QTT)、神经传导检测(NCS)、交感皮肤反应(SSR)检测,其中QTT检测包括四种参数分别为冷感觉阈值(CT)、热感觉阈值(TT)、冷痛觉阈值(CPT)和热痛觉阈值(HPT),并对其结果分别进行统计学分析
2、。结果:@CT、TT、CPT、HPT异常率分别为39.58%、47.29%、64.58%、71.67%,TT异常率高于CT,HPT异常率高于CPT,差异有统计学意义(P<0.05)。②下肢CT、TT、CPT、HPT异常率分别为51.67%、94.58%、62.08%、85.00%;上肢CT、TT、CPT、HPT异常率分别为22.33%、34.59%、32.5%、58.33%,下肢CT、TT、CPT、HPT异常率均高于上肢,差异有统计学意义(P<0.05)。③糖尿病患者在无、轻、中、重症状组中CT异常率分别为19.17%、31.2
3、5%、43.94%、76.19%:无、轻、中、重症状组中TT异常率分别为41.67%、58.33%、75.76%、90.48%;CT矛IJTT异常率随临床症状递增,无与轻、轻与中、中与重症状组在CT或1vr上对比,差异具有统计学意义(尸<0.05),CPT和HPT异常率不呈递增。④QTT、NCS、SSR异常率分别为90.83%、25.83%、57.50%,QTT的异常率最高,三组比较差异均具有统计学意义(P<0.05)。结论:QTT检测糖尿病周围神经病变的异常率最高,其中冷感觉阈值、热感觉阈值是诊断DPN,特别是细小有髓和无髓纤
4、维神经病变的敏感指标。关键词:糖尿病周围神经病变;定量温度阈值检测;神经传导检测;交感皮肤反应AbstractABSTRACTobiective:ToinvestigatethesignificanceofnerveelectrophysiologydetectiontechnologyinthediagnosisofDiabeticperipheralneuropathy,especiallythequantit—ativethermaltesting(QTT).Methods:120diabeticpatientswerem
5、easuredforNerveconductionstudies(NCS),Sympatheticskinresponse(SSR)andquantitativethermaltesting(QTT),QTTincludingfourkindsofparametersofcoldperceptionthreshold(CT),thermalperceptionthreshold(TT),coldpainthreshold(CPT)andheatpainthreshold(HPT).Thesenerveelectrophysiol
6、ogicalresultswerestatisticallyanalysed.Results:①TheabnormalrateofCT,TT,CPTandHPTwererespectively39.58%,47.29%,64.58%and71.67%.Thedifferencebetweenthemwasstatisticallysignify—cantrP7、85.00%;theabnormalratesofCT,TT,CPT,HPTinupperlimbwererespectively22.33%,34.59%,32.5%,58.33%;theabnormalratesofCT,TT,CPT,HPTinlowerlimbarehigherthanthoseintheupperlimbs,thedifferenceareobvious.fP<0.05).③TheabnormalratesofCTinthegroupwithnon·symptom,mild,moderateorseve8、resymptomalerespectively19.17%,31.25%,43.94%,76.19%;theabnormalratesofTTinthegroupwithnon-symptom,mild,moderateorseveresymptomare41
7、85.00%;theabnormalratesofCT,TT,CPT,HPTinupperlimbwererespectively22.33%,34.59%,32.5%,58.33%;theabnormalratesofCT,TT,CPT,HPTinlowerlimbarehigherthanthoseintheupperlimbs,thedifferenceareobvious.fP<0.05).③TheabnormalratesofCTinthegroupwithnon·symptom,mild,moderateorseve
8、resymptomalerespectively19.17%,31.25%,43.94%,76.19%;theabnormalratesofTTinthegroupwithnon-symptom,mild,moderateorseveresymptomare41
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