欢迎来到天天文库
浏览记录
ID:33743578
大小:2.30 MB
页数:55页
时间:2019-02-28
《轻度认知损害和主诉健忘者两年随访分析》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、●硕士学位论文轻度认知损害和主诉健忘者两年随访研究TheresearchofSubjectiveMemoryComplaintsandMildCognitiveImpairmentfollowingupAbstractBackground:Mildcognitiveimpairment(MCDisasyndromecharacterizedbysubjectiveandobjectivecognitiveimpairmentintheabsenceofdementia.1MCIsubclassificationsincludeallamnesticformcharacterizedbyis
2、olatedmemowimpairmentsandonewithmultiplecognitivedeficits,andnonamnesticformcharacterizedbysingledomainoronewitllmultipledomaincognitiveimpairmentwithoutmemory.Andtheelderwithsubjectivecognitivecomplaintsespeciallymemorycomplaintsmayperformnormallytestedbyneuropsychologicalbattery.Whyithappensandw
3、hatrelationshipbetweenMCIandSMCispaidmoreandmoreattention.2AlthoughitisdocumentedthatpersonswimMCIhaveanincreasedriskofALzheimerdisease㈣,population-basedstudieshaveshownthatonlyone-thirddevelopdementia,whereasothersimprove,revertingtoanormallevelofcognitivefunctioning,andsomedie,suggestingmultiple
4、etiologiesforMCI.MemorylossasthepredominantcomplaintstronglypredictsprogressiontodementiaduetoprobableAlzheimer’SdiseaseO岫)inthoseindividualsthetermamnesticMCI(aMCDisused.Objective:ToexaminethepossibleroleofneuropsychologycaldisturbancesinMCI,weinvestigatedneuropsychologycalsettinginpersons、)I,imM
5、CIinalongitudinalstudy.Specificaimsinclude1)investigatingtheConversionrateofsubtypesofaMCItoAD;2)assessingthecontributionofneuropsychologycaldisturbanceinprogressionfromMCItoADover2years;and3)examiningwhetheranysubtypeofneuropsychologycaltestspredictMCIinpersons、析mSMCs.Methodandmaterials:Subjectsf
6、romMemoryClinicofHuashanhospitalincludingonehundredforteenofwhomettheoperationalcriteriaforMayoClinicdefinedMCIandeightythreeofwhodefinitedasSMCwithomobjectivecognitiveimpairmenttestedbyneuropsychologycalbattary.Theyunderwentmultidimensionalassessmentandaneuropsychologicalbatteryatbaselineandatfol
7、low-up,afterabout2years.DiagnosisfordementiaWasbasedonDSM-IVcriteria.Result:47casesof140elderpeople、析mMCIconverttoADwith44ofamnesticMCIsubjectsincluding17aMCI·-Sand27aMCI·-msubjectsof65progressedtoprobableADwithi
此文档下载收益归作者所有