轻度认知损害和主诉健忘者两年随访分析

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1、●硕士学位论文轻度认知损害和主诉健忘者两年随访研究TheresearchofSubjectiveMemoryComplaintsandMildCognitiveImpairmentfollowingupAbstractBackground：Mildcognitiveimpairment(MCDisasyndromecharacterizedbysubjectiveandobjectivecognitiveimpairmentintheabsenceofdementia．1MCIsubclassificationsincludeallamnesticformcharacterizedbyis

2、olatedmemowimpairmentsandonewithmultiplecognitivedeficits，andnonamnesticformcharacterizedbysingledomainoronewitllmultipledomaincognitiveimpairmentwithoutmemory．Andtheelderwithsubjectivecognitivecomplaintsespeciallymemorycomplaintsmayperformnormallytestedbyneuropsychologicalbattery．Whyithappensandw

3、hatrelationshipbetweenMCIandSMCispaidmoreandmoreattention．2AlthoughitisdocumentedthatpersonswimMCIhaveanincreasedriskofALzheimerdisease㈣，population-basedstudieshaveshownthatonlyone-thirddevelopdementia,whereasothersimprove，revertingtoanormallevelofcognitivefunctioning，andsomedie，suggestingmultiple

4、etiologiesforMCI．MemorylossasthepredominantcomplaintstronglypredictsprogressiontodementiaduetoprobableAlzheimer’SdiseaseO岫)inthoseindividualsthetermamnesticMCI(aMCDisused．Objective：ToexaminethepossibleroleofneuropsychologycaldisturbancesinMCI，weinvestigatedneuropsychologycalsettinginpersons、)I，imM

5、CIinalongitudinalstudy．Specificaimsinclude1)investigatingtheConversionrateofsubtypesofaMCItoAD；2)assessingthecontributionofneuropsychologycaldisturbanceinprogressionfromMCItoADover2years；and3)examiningwhetheranysubtypeofneuropsychologycaltestspredictMCIinpersons、析mSMCs．Methodandmaterials：Subjectsf

6、romMemoryClinicofHuashanhospitalincludingonehundredforteenofwhomettheoperationalcriteriaforMayoClinicdefinedMCIandeightythreeofwhodefinitedasSMCwithomobjectivecognitiveimpairmenttestedbyneuropsychologycalbattary．Theyunderwentmultidimensionalassessmentandaneuropsychologicalbatteryatbaselineandatfol

7、low-up，afterabout2years．DiagnosisfordementiaWasbasedonDSM-IVcriteria．Result：47casesof140elderpeople、析mMCIconverttoADwith44ofamnesticMCIsubjectsincluding17aMCI·-Sand27aMCI·-msubjectsof65progressedtoprobableADwithi