大鼠脑缺血再灌注组织中e-选择素和mpo表达变化与阿托伐他汀对其的影响

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1、颂十学位论文-I，文摘耍同，仍以12h达高峰，假手术组基本无阳性表达，干预组则出现在各时间点均显著低于实验组，同样P

2、tobjective：OurobjectiveistostudysequentialE-selectinandmyeloperoxidaseexpressionincerebraltissueafterratcerebralischemia-reperfusion．toascertaintheneuroprotectivemechanismsofAtorvastatinMethods：seventy—tuOhealthymaleSprague-Dawleyrats(240-260)gwererandomlydividedintocontrolgroup，ex

3、perimentalgroupandAtorvastatintreatedgroupEachgroupwasdividedintosubgroupsleach目ouphassixanimals)：4hourSgtoup、8hoursgroupI2hoursgroup．24hornSgroupSprague-Dawleyratfocalcerebralischemia—reperfusionmodelswereestablishedfollowingtheLongasuturemethodInthecontrolgroup，receivedonlyanesth

4、esiaandvascularseparationEachanimalintheinterventiongroupwasreceived6．5mg／kgAtorvastatindailyoneweekbeforetheoperationTojudgethemodelbasesonZealonga’SscoringandTTCstainingresultsWedetectedE—selectinandmyeloperoxldaseexpressioninratbraintissuewithlmmunohistochemicalmethodsExperiment

5、alresultswereanalyzedwiththestatisticsoftpackageofSpss17．0Results：E-selectinexpression：Wefoundfewpositiveexpressionsateachtimepoiminthecontrolgroup(4h，8h，12hand24h)Intheexperimentalgroup，aftercerebralischemia-reperfusion，thevisiblepositivecellswerelargelyinthecoaexandhippocampus．E—

6、selectinwasexpressedat4hBy12h，expressionhadreacheditspeakAt24h，expressionreturntonormallevelsHowever，intheAtorvastatintreatedgroup，E-selectinexpressionwassignificantlylowerthanintheoperationgroupatalltime硕十学＆漳空H录pointsfP‘O05)MyeloperoxidasehadasimilartimingofexpressionchangestoE·se

7、lectin，andthelevelsweresignificantlylowerinthetreatedgroupthanintheoperationgroup(P‘O05)Conclusion：(I)BrainE—selectinandMyeloperoxldaseincreasedaftercerebralischemia—reperfusion，andchangeddynamicallywiththetimeofischemiaE-selectinandMyeloperoxidasealepositivelycorrelatedItisShowedt

8、hatE—selectinandMyel叩eroxi