鼻咽癌放疗后颞叶白质弥散张量系数变化的初步分析

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1、中山大学硕士学位论文中文摘要致了水分子的扩散下降．FA值的下降主要与神经胶质细胞变性、疏松、溶解，使水分子在白质纤维通路方向上的受限程度减低有关．2．1yri可以评价放疗后不同阶段颞叶自质水分子弥散变化的过程，放疗后3～5月双侧颢叶白质的；mCiso值和FA值变化最明显，而随着放疗后时间的延长，6个月以后双侧颞叶A1)Ciso值和FA值均有回升趋势，可能与脑组织细胞肿胀减轻，神经纤维重新髓鞘化有关．总结放疗后颞叶白质弥散特征改变的大致规律，为不同阶段的放疗后改变提供参考依据，以更好地监测放射性损伤的程度以及修复过程，有助于及时发现病变，及时治疗，把放射线对正常组织的损伤减少至最低程度．3．

2、通过I}TI的检查发现，与首程放疗比较，再程放疗组在放疗后3～11月PqhDCiso值和F^值下降更明显，这有可能是再程放疗增加放射性脑病发生率的重要原因．关键词：磁麸振成像；放射性脑病；弥散张量成像V中山大学硕士学位论文英文摘要PreliminaryStudyofTmporalLobeWhiteMatterOlarlgesaferP眦liotherapybyDiffusionTensorImagingMajor：MedicalImaging＆NuclearMedicineGraduate：硎GSilmiSupervisor：ProfessorLIANGBi。—lingABSTRACTBa

3、ckgroundRadiationencephalopathy(REP)isoneofthemostseriouscomplicationsofthepest—radiotheraynasopharengealcarcinomapatients．REPisoftenirreversible，anditislackofeffectivetreatment．Earlydiagnosisandcuringisofprimeimportance．SoImagingandciinicaldepartmentshavebeentakinggreateffortstoexploreadvancedtec

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5、themostpopularresearchtrendinordertoreduceNPCradiationcomplications．Nowadays。investigationsOnREPispronetofunctioinalimagingresearches，amongthem抓mainlyincludingMagneticKesonanceSpectroscopy(MRs)，PerfusionWeightedImaging(PWl)andDiffusionTensorImaging(DTI)．Thesestateofthearttechniquescannotonlyprovid

6、eimportantinformationonfunctionalandmetabolicaspects，andalsomoreaccuratequantitativeanalysiscanbedone．Theycanprovideusefulsupplementaryinformationfortherutine躲exams．IthasbeenquitealongtimefortheinvestigationofMRfunctionalimagingfrOilbothdomesticandabroad。andhasgainmuchachievementOnREPresearcharea．

7、WediscoverMRfunctionalimagingcanapparentlyincreasethedetectionrateofREPoftemporallobes，whichmakespossiblefortheearlypredictioin．ButlimitedbythelocalizedareasNPCpatients，functionalimagingV1中山大学硕十学位论文英文摘要researches