胆胰康对cp大鼠胰腺组织sod活性、血清ha、tgf-β含量的影响 (1)

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1、月H胰康对CP大鼠胰腺组I织SOD活性、血清HA、TGF．B含量的影响ABSTRACTObjective：ToobservetheinfluenceofChineseherbsDan-Yi—Kang(DYK)foreffectonactivationofsuperoxidedismutase(SOD)inpancreatictissueandcontentofhyaluronicacid(HA)transforminggrowthfactor—IB(TGF-13)inseruminordertoexplorethemechanismofDan．Yi—Ka

2、ngtreatingchronicpancreatitis(CP)．Methods：80Sprague—Dawley(SD)ratsweighing230-2709wereputinto2groups：normalcontrolgroupandmodelgroup，normalcontrolgrouphad20rats，modelgrouphad60rats．ModelgroupratsreceivedinjectionofDDCtwiceaweek．Attheendoftheforthweek，10ratsofeachgroupwerekilledto

3、bemeasuredtheactivationofSODinserumandinpancreatictissuetodetectthemodel．TheSurplus10normalratsisthenormalcontrolgroup．Andthesurplus50CPratswererandomlydividedinto5groupseachofwhichhas10rats：modelgroup，losartanadministrationtreatmentgroup，Xiao-Chai-Hu—Tangpilladministrationtreatm

4、entgroup，DYKlow．doseadministrationtreatmentgroup，DYKhigh·doseadministrationtreatmentgroup．Fromthefifthweekfeedtheratsdrags．Attheendoftheeighthweek，allratswerekilledtomeasuretheactivationofSODinpancreatictissueandcontentofHAandTGF-Binserum．Results：Attheendoftheforthweek，themodelgr

5、oup’SactivationofSODinpancreatictissueandinserumweresignificantlylowerthanthenormalcontrolgroup(P<0．01)，andthemodelgroup’SactivationofSODWasonlythe30％ofhenormalcontrolgroup．Attheendoftheeighthweek，thelosartanadministrationtreatmentgroup，theXiao—Chai．Hu．Tangpilladministrationtreat

6、mentgroup，theDYKlow—doseadministrationtreatmentgroupandtheDYKhigh-doseadministrationtreatmentgroup’SactivationofSODinpancreatictissuewassignificantlyhigherthanthemodelgroup(P

7、hetheXiao-Chai—Hu—Tangpilladministrationtreatmentgroup，theDYKlow—doseadministrationtreatmentgroup’ScontentofHAinserumwassignificantlylowerthanthemodelgroup(P<0．05)，andwassignificantlyhigherthantheDYKhigh-dosegroup(P<0．05)，antheadministrationtreatmentgroup’ScontentofTGF一13inserumw

8、assignificantlylowerthanthemodelgroup(P<