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ID:33690863
大小:1.41 MB
页数:33页
时间:2019-02-28
《胆胰康对cp大鼠胰腺组织sod活性、血清ha、tgf-β含量的影响 (1)》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、月H胰康对CP大鼠胰腺组I织SOD活性、血清HA、TGF.B含量的影响ABSTRACTObjective:ToobservetheinfluenceofChineseherbsDan-Yi—Kang(DYK)foreffectonactivationofsuperoxidedismutase(SOD)inpancreatictissueandcontentofhyaluronicacid(HA)transforminggrowthfactor—IB(TGF-13)inseruminordertoexplorethemechanismofDan.Yi—Ka
2、ngtreatingchronicpancreatitis(CP).Methods:80Sprague—Dawley(SD)ratsweighing230-2709wereputinto2groups:normalcontrolgroupandmodelgroup,normalcontrolgrouphad20rats,modelgrouphad60rats.ModelgroupratsreceivedinjectionofDDCtwiceaweek.Attheendoftheforthweek,10ratsofeachgroupwerekilledto
3、bemeasuredtheactivationofSODinserumandinpancreatictissuetodetectthemodel.TheSurplus10normalratsisthenormalcontrolgroup.Andthesurplus50CPratswererandomlydividedinto5groupseachofwhichhas10rats:modelgroup,losartanadministrationtreatmentgroup,Xiao-Chai-Hu—Tangpilladministrationtreatm
4、entgroup,DYKlow.doseadministrationtreatmentgroup,DYKhigh·doseadministrationtreatmentgroup.Fromthefifthweekfeedtheratsdrags.Attheendoftheeighthweek,allratswerekilledtomeasuretheactivationofSODinpancreatictissueandcontentofHAandTGF-Binserum.Results:Attheendoftheforthweek,themodelgr
5、oup’SactivationofSODinpancreatictissueandinserumweresignificantlylowerthanthenormalcontrolgroup(P<0.01),andthemodelgroup’SactivationofSODWasonlythe30%ofhenormalcontrolgroup.Attheendoftheeighthweek,thelosartanadministrationtreatmentgroup,theXiao—Chai.Hu.Tangpilladministrationtreat
6、mentgroup,theDYKlow—doseadministrationtreatmentgroupandtheDYKhigh-doseadministrationtreatmentgroup’SactivationofSODinpancreatictissuewassignificantlyhigherthanthemodelgroup(P7、hetheXiao-Chai—Hu—Tangpilladministrationtreatmentgroup,theDYKlow—doseadministrationtreatmentgroup’ScontentofHAinserumwassignificantlylowerthanthemodelgroup(P<0.05),andwassignificantlyhigherthantheDYKhigh-dosegroup(P<0.05),antheadministrationtreatmentgroup’ScontentofTGF一13inserumw8、assignificantlylowerthanthemodelgroup(P<
7、hetheXiao-Chai—Hu—Tangpilladministrationtreatmentgroup,theDYKlow—doseadministrationtreatmentgroup’ScontentofHAinserumwassignificantlylowerthanthemodelgroup(P<0.05),andwassignificantlyhigherthantheDYKhigh-dosegroup(P<0.05),antheadministrationtreatmentgroup’ScontentofTGF一13inserumw
8、assignificantlylowerthanthemodelgroup(P<
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