异丙肾上腺素对小鼠放射损伤涎腺的作用-研究

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1、遵义医学院颂t一学位论文异丙肾上腺素对小鼠放射损伤涎腺的作用研究产生了严重影响。2．局部X线放射早期可刺激涎腺中大量的干／祖细胞增殖，但在放射后90天时仅残存有少量干／祖细胞。3．IPR对放射损伤涎腺中残存的干／祖细胞具有短时间刺激增殖的作用，从而改善涎腺功能，但长期疗效不佳。关键词：下颌下腺放射损伤干／祖细胞异丙肾上腺素免疫组织化学j兰义[了=：学一，1

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3、三弧：一jf?Hj{1【㈠：EffectofIsoproterenolonIrradiatedSalivar3’GlandsofMicePost

4、graduateHeYuanchunTurtorHuangGuilingSchoolofStomatol093,ZunYiMedicalCollege，GuiZhouZunYi．563003[Abstract]Purpose：Inthisstudy,weusedC57BL／6malemicetobemodelsⅥ，hichwereinjuredbyX。raytosalivarygland．andinjectedtheirradiatedmicefromtheirstomachewithisoproteren01(IPR)．Accordingtothisexperiment．wecan

5、gettheinfluencethatIPRactsonirradiatedsalivaryglandanditsproliferationeffectonsurvivalstem／progenitorcells．whichcanprovidetheorizationforpreventingandcuringirradiatedsalivawglandMeans：Themodelswechosewerehealthymaleadultmice，whichwereattheageof8．12andweighed(20-2=1)g．First，dividedthemiceintothr

6、eegroups：injectedIPRbeforeandafterirradiation(K—IR-K)、irradiatedgroup(IR)andcontrolgroup．Then．observedtheappearanceandweightofeachmouseineachgroup，includingtheweightofsalivarygland，4、10、30、60and90dayslater．aftertheywereirradiated．Andalsocheckedtheirsalivaflowingrateandhowmuchsalivaamylasetheyha

7、d．Atthesametime．checkedHEandtheseimmuseorganizations：Amylase、Laminin、Sca一1andKi一67afterthevwereirradiated4、30and90dayslater．Atlast，comparetherusults．whichweregottenfromabovesteps．amongdifferenttimeandgroupsResults：1-Appearanceandweight：thatthehairofthemicewerebecomingwhitehappenedtothemiceinIRa

8、ndK—IR—Kafterbeingirradiatedfor30days．ThemiceinIRandK—IR-Kbegantoloseweightafterbeingirradiated．butafter5daysorso．theirweightbegantorise．andkeptthesameasbeforeaftertwoweeks．Then．theirweightrosegradually·Howeverthemiceincontrolgroupdidn’tchangeinormallybothinappearanceandweight．2·ChanNngoftheirs

9、alivarygland’sweightandfunction：theweightoftheirsalivaryglandinIRandK—IR—Kdecreasedcontinuously：butthelaterwasheavierthanthefornler(P<0·05)·Andinthesetwogroupsofmice．theirSalivaflowingrateandamylaseamount7j蔓义医学院坝卜≥止论文异}qI譬㈠J永素对小陵b