辨病与辨证相结合治疗白塞病的临床研究

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1、提要目的：本研究通过观察治疗前后白塞病患者疗效性及安全性指标的变化情况，比较两组治疗前后及组间疗效以及复发、不良反应的差异，初步客观评价中医治疗方案的临床疗效及安全性。方法：本试验统计2010.03―2012.02山东中医药大学附属医院风湿病科门诊和住院病人及2010.06―2010.08山东省立医院风湿免疫科住院病人共30例，以1:1比例随机分为试验组和对照组，试验组选用中医辨病辨证方治疗，对照组选用沙利度胺50mg/日治疗，服药2个月，观察两组治疗后白塞病疗效指标、中医症状疗效指标、实验室检查指标；并随访3个月观察复发及

2、不良反应等情况。结果：试验组和对照组在治疗后，在白塞病疗效、中医症状及实验室检查比较方面无显著性差异（P>0.05），试验组的复发率及不良反应发生率均与对照组有明显差异性（P<0.05），优于对照组。结论：中医辨病辨证相结合的思路治疗白塞病取得了良好疗效，并且有效地减少了复发次数，远期疗效较西医好，并有较好的安全性，证明了辨病辨证思路的正确性。关键词白塞病；辨病辨证相结合；临床研究ClinicalresearchonBehcet'sdiseaseTCMTreatmentBasedonCombinationofDiseasea

3、ndSyndromeSpeciality:InternalMedicineofTCMRheumaticDiseaseAuthor:WangLinglingTutor:Prof.SongShaoliangAbstractObjective:OurresearchaimstoevaluatetheclinicalefficacyandsafetyofTCMtreatmentbycomparingcurativeeffectindexes,safetyindexes,relapseandadversereactionsbetwee

4、nthetreatmentgroupandcontrolgroup.Methods:30patientswererandomlydividedintotreatmentgroupanddcontrolgroup,thetreatmentgrouptreatedwithChinesemedicinebydiseasesyndromesandthecontrolgroupselectedThalidomide50mg/day.Treatfor2monthstoobservethevarietiesofindexessuchasc

5、urativeeffectindexandindexofsyndromeofTCM,andfollowupfor3monthstowatchrecurrenceandadversereactions.Results:Wecomparedtreatmentgroupwithcontrolgroupaftertreatment,theefficacyinBehcet'sdisease,clinicalsymptoms,laboratorytestswerenosignificantdifferences(P>0.05),rela

6、pserateandadversereactionsofthetreatmentgroupweresignificantdifference(P<0.05)thanthecontrolgroup.Conclusion:TheTCMtreatmentbasedoncombinationofdiseaseandsyndromeofBehcet'sdiseasehasmadeagoodeffectandbettersecurity,iteffectivelyextendtherecurrenceoflong-termeffectt

7、hantheWestern.Ourresearchofthisdissertationhasbeenprovedtoberight.KeywordsBehcet'sdisease；CombinationofDiseaseandSyndrome；Clinicalresearch目录引言...........................................................................................................................

8、....1临床研究...............................................................................................................................2一、试验设计..