elekta – the particle therapy story科达–颗粒治疗的故事

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1、TheParticleTherapystory.Clinicaltreatmentsusingbothprotonandcarboniontherapyarenotnewtoradiationoncology.Thesetreatmentmodalitieswerefirstusedin1954[SourcePTCOGBerkeley,CA,USA]andsincethistimetherehavebeenover70051[SourcePTCOGDecember2008]patientstreatedtodate.Whataretheperce

2、ivedadvantagesofparticletherapy?Theadvantagesofparticletherapyincomparisontoradiotherapywithphotonsareimproveddoseconformityinsidethetumoraswellasthelowerintegraldosedepositedinthehealthytissuesurroundingthetumor.Thelowerintegraldoseisaconsequenceofthephysicaldifferencesofpar

3、ticlestophotonsandthenatureofthedosedeposition.Havinganon-negligiblemass,mostoftheenergyoftheparticlesisdepositedinsidethetumoratthedepthofthesocalledBraggpeak.Inclassicalphotonradiotherapy,thedoseisdepositedrandomlyalongthewholepathoftheradiation,withenergydepositionatitshig

4、hestwithinthefirstfewcentimetersofthebodysurfaceandcontinuingthroughoutthebody.Asidefromthepossibilityoftreatingtumorsresistanttoclassicalphotontherapy,thespecialphysicalpropertiesofparticlesallowthetreatmentofdeep-seatedtumorswithahighintegraldosetohealthytissuewhileonitsway

5、tothetumor.Particletherapyisalsofavorablefortumorsinthevicinityofsensitiveorvitalorgansduetothehigheraccuracyofthistreatmentmethodandthesteepdropoffatthefaredgeofthetumor.Becauseofthedecreasedenergydepositioninhealthytissueandoveralllowerintegraldose,theprobabilityofdevelopin

6、gsecondarycancerinthetissuesurroundingthetumorisstronglydecreased.Thereforeparticletherapyisespeciallysuitedforpediatrictumors.Thisisespeciallyimportantduetothelonglifeexpectancyofchildrenafterirradiationandthehighriskofsecondarycancerandincreasedlocaltissuetoxicitycausedwhen

7、treatingthemwithclassicalphotontherapy.Whythesuddeninterestinthistechnology?Thelastthreeyearshasseenadramaticsurgeinthecommercializationofparticletherapy.Currentlythereare12manufacturerseithersupplyingordevelopingPTaccelerator,6TPSvendorsornumerous“turn-key”solutionproviders.

8、Wehaveseen6newPTfacilitiesbecomeclinicalintheiroperationsoverthelast