紫外线致皮肤成纤维细胞和角质形成细胞中的自噬研究

《紫外线致皮肤成纤维细胞和角质形成细胞中的自噬研究》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、博士学位论文学校代码：10023学号：B2009425紫外线致皮肤成纤维细胞和角质形成细胞中的自噬研究所院：姓名：指导教师：导师小组：学科专业：研究方向：完成日期：皮肤病研究所陈旭顾恒主任医师李新宇研究员陈嵬主任医师皮肤病与性病学光线性皮肤病2012年5月1日DoctoraldissertationAutophagyinskinfibroblastandkeratinocytewhichwereexposedtoultravioletirradiationByChenXuUnderthesupervisionofProf．GuHeng

2、Prof．LiXinyuProf．ChenKunInstituteofDermatologyChineseAcademyofMedicalSciences&PekingUnionMedicalCollegeMay2012本研究由下列科研基金资助：l、2011年国家自然科学基金面上项目《慢性紫外线损伤致皮肤成纤维细胞自噬发生的分子机制研究》，811715132、2008年国家自然科学基金面上项目《自噬与人皮肤成纤维细胞光老化关系及相关信号调节的研究》，308722683、2011年度高等学校博士学科点专项科研基金《调控自噬药物的抗皮肤光

3、老化效应的分子机制研究》，201111061100414、2010年江苏省自然科学基金《中波紫外线对人角质形成细胞光损伤中的自噬研究》，BK20101355、2009年天津市卫生局科技基金项目《人皮肤光老化模型动物小鼠皮肤的角蛋白表达研究》，09KZ52目录中文摘要(关键词)·····················································1英文摘要(关键词)·····················································3弓I言············

4、······················································6正文·································································12第一部分：中波紫外线诱导人皮肤成纤维细胞自噬对凋亡影响的初步研究···············································12研究背景及研究目的概述·······································12材料和方法········

5、···········································12结果·························································14讨论·························································21参考文献·····················································22第二部分：凋亡和自噬交互调控元件Bax、Bcl．2、Beclin．1在慢性紫外线损伤小鼠

6、模型皮肤角质形成细胞中的表达研究·········24研究背景及研究目的概述·······································24材料和方法···················································24结果·”········一·······”一····””··一··””······”··一·”25讨论·························································31参考文献···················

7、··································32第三部分：中波紫外线对体外培养的人角质形成细胞系HaCaT细胞自噬调控效应研究·······································35研究背景及研究目的概述·······································35材料和方法···················································35结果··········一··”····一一·····一一·······一一···”·一

8、···”37讨论·························································4l参考文献·······································