运动训练对大鼠运动区域皮质梗死灶周nogo-a的表达、血清tnf-α水平的影响

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1、万方数据四川医科大学硕士学位论文builttheMCAOmodelinratsbyapplyingLongathreadcork．Therestofthe56ratsrandomlydividedintothemodelgroupandthetraininggroup．Afterthesurgery,accordingtotheLongaassessmentforbehaviorscore，score1-3asthesuccessfulmodelwereusedforresearch．Thetraininggro

2、upreceivedtrainingintervention．2、Outcome：@EachgroupwereselectedtodoevaluationsbymNSS，7ratsfromeachweretakenbloodandbrainsampleatthedayl，7，14，and28postMACOprocedures，andthen；③WeobservedthepathomorphologicalchangeofcerebraltissuesthroughHEstain，anddeterminedthe

3、leverofTNF一0【byELISAandexpressionofNogo—AininfarctionboundaryzoneofcerebralmotorcortexbyIHC．3、Statisticalmethods：StatisticalanalysiswasperformedusingSPSS19．0forwindowssoftware．X士swasusedtoexpresstheresult，one—wayanalysisofvariancecouldbeusedinitandP<0．05wasst

4、atisticallysignificant．Results：1、mNSS：ThemNSSscoresofthetraininggroupandthemodelgroupaftermodelingldweregraduallydeclining．Whenmodelingafterld，scoresbetweenthetwogroupswasnotstatisticallysignificant(尸>O．05)．Thelimbfunctionwashigherintraininggroupthanthatincon

5、trolgroupat7d，14d，and28daftercerebralinfarction俨<0．05)．2、HEstainobserving：RegionalcerebralcortexmovementofThenormalgroup，neuronsinthehippocampusaligned，didnotseethePathologicalchanges．ModelgroupvisiblestructureChange，thedecreaseinthenumberofcells，cellswerearr

6、angeddisorder．Morecellweredamaged，Karyopyknosisandhyperchromatic，thetraininggroupcomparedwithmodelgroup，theformerchangedrelativelygently．3、．5．万方数据四川医科大学硕士学位论文Nogo—A：Analysisofthequantitativeimmunohistochemistry,Exercisetraining(7d，14dand28d)canreducetheexpres

7、sionsofNogo—A，Thedifferencebetweentheexercisetraininggroupandmodelgroupwerestatisticallysignificant(P

8、roupandthetraininggroupinTNF一0【levelbegantodrop，Comparedwiththeexercisegroup，themodelgroupdropslowlier,thedifferencewassignificant(P