重组合bmps在羊下颌骨较大速率牵引成骨术中的应用分析

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1、上海第二医科大学2001级口腔临床医学硕士学位论文ExperimentalStudyofApplicationofBMPsinMandibularLengtheningatHigherRateofDistractioninaGoatModelABSTRACTDistractionosteogenesis(DO)canbedefinedasamethodofboneandaajacentsoiltissuelengtheningmakeuseofthefactthatosteogenesisisind

2、ucedatanosteotomygapwhendistractionwithdistractorisapplied．DOthatisregardedasaneffectiveapproachorafonnofvivoendogenousbonetissueengineeringissuperiortotraditionalsurgeryinmanyaspects．itiswidelyusedintreatmentofcongenitalandacquiredcranio-maxillofacial

3、defectsordeformities．However,thelongdurationoftheboneconsolidationanddistractionperiodofDOtreatmentcanbeacauseofconsiderablecomplicarlonsforthepatients，suchaSsonlecomplicationscausedbyindwellingdistractorinbodychronically,bonymal-union，sociableandmenta

4、lhandicapandSOon，whichwillbaffleandlimitwidespreadapplicationofDOandinclinicalpractice，thereisaburningneedforaugmentationofboneconsolidationandincreasingrateofdistractiontoshortenthelongprocedureofDO，TheprocedureofDOhasbeendividedorderlyintofourstagesi

5、nclinicpractice，i．e。operationperiod，latencyperiod，distractionperiod，consolidationperiod．Latencyperiodcanbeshortenedto3’、。5daysoracertainosteotomygapbecreatedintraoperativclybyreasonofenoughbloodsupplyincranio—maxiltofacialregion，TheIorgprocedureofDOwil

6、lbeinfluencedimaginablybytworeasonsasfollows．Firstly,slowdistractionperiod，whichisinfluencedprimarilybythedistractionrateandamountoflengthening．Secondly,longerconsolidationperiod，whichis5上海第二医科大学2001级口腔临床医学硕士学位论文influencedbythecapabilityandspeedofboneu

7、nionandcalcification，andaswellascausedbythedistractionrategreatly．Thespeedofboneunionandconsolidationwillbeslowwhenlengthenedatahigherrate(>1．3mm／d)，anddelayedunionornonunionconsistedoffibro-unionmayarisesimultaneously．Itisunknownatpresenthowthemethani

8、smsthatregulateboneformationaretranslatedintobiologicalsignalsduringDO，Multiformlocalcytokinesthatstimulateosteoblastactivityandspeedconsolidationhasbeentestifiedinavarietyofanimalresearches．Bonemorphogeneticproteins(BMPs)isadifferentia