低强度脉冲超声在beagle犬牙槽骨与颌骨缺损模型中促进骨质修复的初步分析

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1、重庆医科大学硕士研究生学位论文mandiblebonedefectmodelastheauxiliarycontrolgroup．ToprovidethecomparisonandinitialbasisinthefurtherapplicationofLIPUSforthetreatmentofperiodontaldisease，weexploredthebiologicaleffectsofLIPUSinthealveolarboneandmandibledefectmodels．ThepreliminarystudyoftheeffectofLIPUSonpromotingbon

2、erepairinBeagledogs’mandibularpremolarsalveolarbonedefectmodel．Objectsofthisstudywerethebilateralmandibularthirdandfourthpremolarsof2adultmaleBeagledogs．Weestablishedthealveolarbonedefectmodelsbyremoving6mmbuccalalveolarboneundertheCEJ(thecementum‘enameljunction)byperiodonmlsurgery．Theexperimenta

3、lgroupandthecontrolgroupwererandomlyselected．LIPUS(ISATA30roW／cm2，1．5MHz，2009s，1KHz)treatedtheexperimentalgroup20minutesperday,atotalofeightweeks．Resulstofperiodontalclinicalexamination(GI，PD，AL)showedthatexperimentalgroupperiodontalClinicalsymptomswaslessseriousthanthecontrolgroup．Dual—energyX-r

4、aybonemineraldensity(BMD)inspection：experimentalgroupwasO．6689土0．05989／cm2，andcontrolgroupwas0．6353士0．0600g／cm2．Histopathologicalanalysis(HE，MASSON)：Intheexperimentalgroup，thenewlyformedalveolarbonecollagenwasobviouslyreddyed．Thebonewasdyedwithred，andtheredareaaroundthecartilagewaslargerandshowed

5、ahigherdegreeofcalcificationthanthecontrolgroup．Imagingandhistologicalanalysis6重庆医科大学硕士研究生学位论文showedthatLIPUScouldincreasethelevelofcalcificationandbonedensity,promotethenewlyformedbonetorebuildmatureorganizationalstructure．ThisexperimentsuggestedthatthespecificparametersofLIPUSmayhaveacertaineff

6、ecttopromotethealveolarboneregenerationandrepair,however，furtherstudyisneeded．PARTIIThepreliminarystudyoftheeffectofLIPUSonpromotingbonerepairinBeagledogsmandibledefectmodel．Weestablishedoneroundbonedefect(diameterof5mm，deepof4mm)onbothsidesofthemandibleintwomaleBeagledogsbyperiodontalsurgery．The

7、experimentalgroupandthecontrolgroupwasrandomlyselectedforthisstudy．LIPUS(ISATA30mW／cm2，1．5MHz，2009s，1KHz)treatedtheexperimentalgroup20minutesperday,atotalofsixweeks．Dual。energyX-raybonemineraldensity(BMD)inspection：exp