经尾静脉移植骨髓间充质干细胞治疗大鼠脑缺血再灌注损伤的实验分析

《经尾静脉移植骨髓间充质干细胞治疗大鼠脑缺血再灌注损伤的实验分析》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、天津医科大学硕士学位论文(PO．05)；4．Double-stainingcellsofimmunohistochemistrycouldbefoundatthecenterofdamagesite，choroidplexus，aroundependymallayerandtheperivascular．BrdU+cellsandImmunohistochemicaldoublestainingpositivecells(Brdu+MAP．2，Brdu+

2、GFAP,Brdu+vWF，Brdu+VEGF)wereseeningroupAandgroupB．Conclusion：1．BMSCscouldseparatedandamplificationinvitro．2．ImprovedsuturemethodiSsimpleandreliable．ItCanbeusedintheresearchoffocalcerebralischemia-reperfusioninjury．3．BMSCstransplantedthroughvenacaudaliscallsurviveanddifferentiateinthehostbr

3、aindamageregion．BMSCstransplantationisabletoimprovetherecoveryoftheneuralfunctionofcerebralischemiainjuredrats．Themechanismmayberelatedtothetransplantedcellsdifferentiatingintoneuron-likeandglial—likecells，angiogenesis，andsecretionorpromotingthesecretionofneurotrophicfactorsofhostcells．4．T

4、heefficacyisrelatedtothenumberofBMSCs，3×10木6hasabettertherapeuticeffect．5．Immunologicalrejectionandtumourformationdonotdetectedinhost．Keywords：bonemarrow-derivedmesenchymalstemcells；MCAO；venacaudalistransplantation；SDratsIV天津医科大学硕士学位论文目录中文摘要⋯⋯⋯OQ⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯0gimll⋯⋯⋯⋯GIAbstract⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯

5、⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯II缩略语／符号说明⋯⋯⋯⋯O010⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯V前言⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯1日U吾⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯l研究现状、成果⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯1研究目的、方法⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯2对象和方法⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯3结果⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯14讨论⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯2

6、0结论⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯32参考文献⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯34发表论文和参加科研情况说明⋯⋯⋯⋯⋯⋯0Q⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯39综述⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯40骨麓充质干细胞移植治疗缺血性卒中的研究进展⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯40综述参考文献⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯46致调十⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯D0⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯51V天津医科大学硕士学位论文缩略语／符号说明MCAOMiddleCerebralArteryOcc

7、lusion大脑中动脉栓塞BMSCsbonemarrowmesenchymalstemcells骨髓间充质干细胞MSCsmesenchymalstemcellsCNScentralnervoussystemmNSSvWFNestinGFAPMAP．2VEGFMPOBDNFTTCCCAECA间充质干细胞中枢神经系统modifiedneurologicalseverityscore改良神经功能评分VonWillebrandfactorNestinGlialfibrillaryacidproteinvWF因子巢蛋白神经胶