糖肾宝治疗早期糖尿病肾病的临床观察

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1、提要目的：观察糖肾宝联合缬沙坦胶囊（代文）治疗早期糖尿病肾病的疗效。对象与方法：1、100例DN患者，随机分为2组。治疗组55例、对照组45例，病程5～15年。2、治疗组采用基础治疗方案加缬沙坦胶囊(代文)加糖肾宝；对照组采用基础治疗方案加缬沙坦胶囊（代文），两组均治疗1个月，同时观察治疗前后两组症状改善率及实验室相关指标。结果：治疗组能显著改善患者症状，与对照组比较有显著性差异（P<0.01或P<0.05）；治疗组尿微量白蛋白排泄率、血糖、血脂、尿α1微球蛋白及血液流变学指标治疗后均较治疗前有显著改善（P<

2、0.05或P<0.01），与对照组比较有显著性差异（P<0.05）。结论：糖肾宝联合缬沙坦胶囊对早期糖尿病肾病疗效明显优于单纯西药治疗本病，可明显改善患者症状，降低尿白蛋白排泄率、尿α1微球蛋白,降低总胆固醇及甘油三酯，升高高密度脂蛋白，改善血液流变学，保护肾脏。关键词糖肾宝；早期糖尿病肾病；益气养阴活血法TheclinicalobservationofTangShenBaoonearlystageofdiabeticnephropathySpeciality:CombinationofTraditional

3、ChineseandWesternMedicineClinicalAuthor:NZhaoNaZhaoTutor:iProfessorLinmaoMunmaoMuAbstractObjective:ToobservethecombinedTangShenBaovalsartancapsules(Diovan)inthepatientswithearlydiabeticnephropathy.CombinationofChinesetraditionalandWesternmedicinetherapyonea

4、rlydiabeticnephropathyindiabeticnephropathyadvantages,safe,effective,convenientprescriptionoftraditionalChinesemedicineandthetreatmentmethod.Method:1.100patientswithDN,wererandomlydividedinto2groups.55casesinthetreatmentgroup,45casesinthecontrolgroup,thecli

5、nicalcourseof5～15years.Two2casesofgeneralinformationbyXtest,nosignificantdifference(P>0.05),comparable.2.basisfortreatment,thetreatmentgroup+valsartancapsules(Diovan)80mgonetimeadaysugarrenaltreasure;thecontrolgroup:basictreatment+valsartancapsules(Diovan)8

6、0mgonetimeaday,NovartisChina,onemonthforaperiod.Statisticalmethods:alldatatodealwithSPSS15.0software.Datatomean+SD(⎯x+s),measurementdatausingttest,countdatausingX2test,Pvaluelessthan0.05consideredthedifferencewasstatisticallysignificant.Result:comparisonofr

7、esultswithTangShenBaotreatmentgroupsurinaryalbumin,lipidbloodrheology,urineα1microglobulininpatientsbeforeandaftertreatmentwassignificantlylower(P<0.05orP<0.01)；onthebloodglucoseandglycatedhemoglobinhasacertainimprovingeffect.Conclusion:Thecombinationofdise

8、aseandsyndromedifferentiation,TangShenBaocombinedwithvalsartancapsuleintreatingearlydiabeticnephropathymicroalbuminuriahasremarkablecurativeeffectespeciallydecreasingonUAER、urineα1microglobulin、TCandTG