欢迎来到天天文库
浏览记录
ID:33018013
大小:3.94 MB
页数:47页
时间:2019-02-19
《基于影像学的胰腺囊性肿瘤评估模型的建立与临床应用》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、万方数据Anevaluatingmodelforpancreaticcysticneoplasmbasedonimaginganditsclinicalapplications·ZhejiangUniversitySchoolofMedicinePurpose:Postgraduate:XiaoYongShenSupervisor:ShuSenZhengAbstractToexploreasimpleandreliablenon—invasivedistinguishingsystemforthepr
2、e.operativeevaluationofmalignancyinpancreaticcysticneoplasm(PCN).Discoveringfactorspredictingmalignancythroughmedicalimagingandclinicalinformaticsstudy,buildingadistinguishingmodelformalignancytOassistdiagnosisandtherapyfortheclinicalpractice.Methods:Th
3、isstudyfirstenrolled锄nobservationcohortof102consecutivePCNpatients.Demographicinformation,resultsoflaboratoryexaminations,andcomputedtomography(CT)presentationswererecordedandanalyzedtOachieveadistinguishingmodel/systemformalignancy.Agroupof21patientswa
4、sthenincludedtovalidatethemodel/systemprospectively.Resuits:BasedOnthe1malignancy—relatedfeaturesidentifiedbyunivariateanalysis,aIV万方数据浙江大学硕士学位论文英文摘要distinguishingmodelformalignancyinPeNwasestablishedbymultivariateanalySis:PCNmalignantscore=2.967×elevat
5、edfastingbloodglucose(FBG)仑6.16retool/L)-4-4.496×asymmetricallythickenedwall(ormuralnodules三4rnm)-4-1.679×septumthickening仑2mm)一5.134.Withtheoptimalcut-offvalueselectedas-2.8inreferencetotheYoudenindex,theproposedsystemformalignantPeNwasestablished:sept
6、umthickening(>2mm),asymmetricallythickenedwall(ormuralnodules>4nun),orelevatedFBG(>6.16mmol/L,accompanyingcommonlyknownmalignantsigns),thepresenceofatleastoneofthese3featuresindicatedmalignancyinPeN.Theaccuracy,sensitivityandspecificityofthissystemwere8
7、1.4%,95.8%and76.9%,respectively.MRlwasperformedon32patients,makiIlgcorrectpredictionofmalignancyexplicitlyinonly68.8%(22/32).Thesubsequentprospectivevalidationstudyshowedthattheproposeddistinguishingsystemhadapredictiveaccuracyof85。7%(18/21).Moreover,ah
8、ighermodelscore.oraggregationofthefea缸】resintheproposedsystem,indicatedahighergradeofmalignancy(carcinoma)inPeN.Conclusion:ElevatedFBG(>6.16retool/L),asymmetricallythickenedwall(ormuralnodules>4nun)andseptumthickening(>2lnln)areo
此文档下载收益归作者所有