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ID:33007405
大小:2.06 MB
页数:54页
时间:2019-02-19
《_27131_ⅰ治疗分化型甲状腺癌骨转移的临床分析》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、中文摘要mI治疗分化型甲状腺癌骨转移的临床研究缓解、病灶保持稳定或缩小,是治疗DTC骨转移的有效手段;单发病灶、单纯骨转移、手术联合131I治疗者预后更好。.关键词:分化型甲状腺癌;骨转移;影像学比较;放射疗法;碘放射性同位素治疗;疗效评价Ⅱ作者:邱忠领指导教师:罗全勇ClinicalStudyof”1IfortheTr—ea—tmentofBoneMeta⋯stasesfrom—Differentiate—dThyroidCancer一.垒!!塑堕Studyof131IfortheTreatmentofBoneMetastasesfromDiffere
2、miatedThyroidCancerAbstractobjectiveBoneisthesecondmostfrequenttargetofdistantmetastasesinDTCpatients.Thetreatmentofbonemetastasis(BM)inassociation谢廿ldifferentiatedthyroidcancer(DTC)representsadifficultchallenge.GiventhepaucityofpatientswithBMandthedifficultyoftreatingthisdisease
3、,fewstudieshaveinvestigatedBMfromDTC.TheaimofthisstudyWastoidentifytheclinicalfeaturesofDTCpatientswithBM,tocomparethevalueofvariousimageologicalmethodsinthedetectionofBMfromDTC,toevaluatetheefficacyof1j1Itreatmentandidentifyitsinfluencingfactors,andtoanalyzethesurvivalratesafter
4、131Itreatmentanditsinfluencingfactors.。MethodsTheclinlicaldataof106DTCpatientswithBMtreatedby1311weieretrospectivelyanalyzed.Thedetectionrateof乃1I-WBS,bonescintigraphyX-ray,CT,MRItodetectBMwerecompared.E伍cacyafter1,1Itreatmentwasassessedbasedonthedynamicchangeofserumthyroglobulin
5、,thepalliationofbonepainandthechangesofimageology.Thevariablesaffectingtheresponseof151Itreatmentwereidentifiedusingunivariateanalysis.SurvivalrateafterBMdiagnosiswereestimatedusingthelifetablemethod.TherelationshipbetweensurvivaltimeandseveralvariableswereassessedusingKaplan—Mei
6、ermethodforunivariatesanalysis.ResultsTheincidencerateofBMWrits8。4%(106/1258)inDTCpatientsinthisstudyandmostofthemwereosteolyticlesions.Ribs,iliumandthoracicvertebratewerethemostcommonsitesofBMinD1℃.Twenty-onepatients(19.8%)presentedwithBMastheinitialpresentationofDTC.BMWasmoreco
7、mmoninpatientsover45yearsold,andwasoftenmulfieentric.Thedetectionrateof131I-WBS,'MⅪ,bonescintigraphy,X-ray、CTtodetectBMwere93.8%、96.6%、47.3%、66.5%、38.2%,respectively.Aftermultiple131Itreatment,serumthyroglobulinlevelweredroppedmarkedlyin34.9%patientsandkeepstablein52.8%patients.B
8、onepainWaspalliatedin39(63.9%)of61patien
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