旋磁场对大鼠脑缺血再灌注损伤的影响

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1、Theeffectofrotatingmagneticfieldonischemia．—reperfusioninjuryofthebraininratsABSTRACTPrefaceWiththechangeoflivingstyleandtheagingintheworld，cere—brovasculardiseaseisbecomingamajordeathreasonforhumanbe—ings．85％ofthecasesforcerebrovascnlardiseasedeathiscaus

2、edbycerebralischemialedbybloodvesselsblockageinoroutofthebrain．Thus．it§extremelyurgenttostudythepreventionandtreatmentofis—chemiccerehrovasctdardisease，andreleasethethreatofthisdiseasetohumanhealth．UptonOW，thestudyofthrombolytictherapyofis·chemiccerebrova

3、sculardisease，nutritionaltreatmenttobrainceils，andsupportingtreatmenthavebeencarriedout．Thestudyoftheeffectofphysicalfactoronischemiccerebrovasculardiseasealsomakescertainprogress．Asakindofphysicaltreatmentmethodonis—chemiccerebrovasculardisease，magheticf

4、ieldhasbeenpreliminarilyprovedtobevalueandsafety．It§foundthatthemagneticfieldmaycauseaseriesofbiologicaleffectonorganism．Themagneticfieldmayenlargebloodvessels，speedupbloodflow，improvemicroeirculation；enhancethedegenera-tioncapabilityofredbloodceHs，reduce

5、itsaggregation，andlowerbloodviscosity．Thus，themagneticfieldhasthefunctionsofanti—in-flammation，promotingthemetabolismoftissuesandceHs．Atthesametime，themagneticfieldmayalsoprohibitfreeradical，improvetheantioxidationphylacticpower，andreleasetheinjuryoftissu

6、eultra·5·一micro—structure。Magneticfield，sfunctionsonpromotingtissuehealing，skeletongrowth，fracturehealingandpreventingsearsalsohavebeenproved．Accordingtotheabovementionedbiologicaleffects，tlleexperi-mentalresearchesofmagneticfieldonischemiccerebrovascular

7、dis—easehasbeendone．Themagneticfieldsappliedare：rotatingmagnet-icfield(RMF)，constantmagneticfield(CMF)，pulseelectromagnet-icfield(PEMF)，etc．ThisexperimentuseRMFontheacutefocalcerebralischemia—reperfusedrats．observetheinfluenceofRMFOilthevolumeofcerebralin

8、farction．cerebraledemaandtheradicalme—tabolismsoastostudyfurtherwhetherRMFmaypreventandtreatfo-calcerebralischemiareperfusionandthesafetyofitsearlyapplica-tion．Materialandmethods128healthyWistarratsaredividedintogro