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1、上海交通大学硕士学位论文天，对照组为11.67天，P＝0.003，P<0.05,两组间有显著性差异。术后PRP组和对照组在骨折愈合方面，X线上显示，术后1个月、术后3个月、术后6个月和一年时在骨痂生长的面积和密度上未见有明显好于对照组。因此，术后PRP组和对照组在X线上提示在骨折愈合方面未见明显差异。但是，患者在术后骨折的功能康复上，PRP组和对照组有显著差异。骨折术后功能康复结果：上肢患者6周时平举1Kg重物平均时间：PRP组54.523±8.224秒；对照组33.233±6.426秒。下肢患者10周后不扶拐行走30步所需的时间：
2、PRP组146.335±10.725秒；对照组98.253±15.162秒。功能评定结果两组比较P=0.036（P<0.05）,差异有统计学意义。结论：PRP能加快伤口的愈合，没有增加患者伤口的不良反应，缩短了住院天数。PRP对骨折修复的影响在X线上未见明显的促进作用，但是明显促进患者骨折的功能康复。关键词：富血小板血浆，骨修复，软组织修复，生长因子2上海交通大学硕士学位论文CLINICALSTUDYOFIMPROVEBONEANDSOFTREPAIRWITHPLATELET-RICHPLASMAABSTRACTOBJECTIVE：
3、Tostudytheimproveofplatelet-richplasmatoimprovethebonerepairintheclinic.METHOD:FromAugust2007toDecember2007,59casesmatchwiththecon-ditionoffreshfracturedivideintotwogroups.With29inexperimentgroup,19maleand10female,10to57yearsold,43.62±10.15inmean;with30incontrolgroup,1
4、9maleand11female,22to57yearsold,35.0±9.92inmean.30mlbloodcollectedfromsamples,5-7mlPRPwasseparatedaccordingtwicecentrifugalizationoftraditi-On,theninjectthebrokenendsoffracturedbonebythedoctorwhentheopenredu-ctionandinternalfixation（ORIF）wascompleted.Thecontrolgroupwit
5、hORIFmerely.Toobservationthenormalconsequenceoftheoperativeincision,adverserea-ctionoftheoperativeincision,thehospitalday,thehealingofthebone.woobserveallofthepatientsbonehealingatthetimein1stmonth、3rdmonth、6thmonth、ayearfromtheX-ray,thetwosideofthedensityandtheareaaro
6、undthebrokenendsoffracturedbone.Wecomparedthefunctionalrehabilitationoffracture,upperlimb,bythetimeoneminuteforstandard,thetimeforthepatientliftonekilogramload8Wpostoperation.lowerlimb,bythetime3minutesforstandard,thetimeforpatientstowalkwithoutthecanefor30steps10Wpost
7、operation.3上海交通大学硕士学位论文RESULT：Allpatientswerefollowedupfor6to12months.Allofthefracturewashealedwhenthefollow-upperiodcompleted,andnononunionoccurrenced.Sco-reoftherepercussionofthecutinPRPgroupwas26.706comparedwith33.183inthecontrolgroup,showingnosignficantdifference(P
8、>0.05).ScoreofthegradeofcuthealinginPRPgroupwas29.500comparedto30.534inthecontrolgroup,alsoshowingnosignificantdiffer
