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1、结核蛋白芯片检测在结核病诊断与治疗中价值基金项目攀枝花市应用技术研究与开发项目（项目编号：2013CY-S-16-10）doi：10.3969/j.issn.1007-614x.2014.10.69摘要目的：探讨结核蛋白芯片检测在结核病诊断和疗效观察中的价值。方法：使用蛋白芯片系统检测血清结核抗体的病例共3676例，其中结核病例407例，非结核病例3269例。采用蛋白芯片技术检测结核杆菌中5种成分，即ESAT-6.CFP10、LAM、38KD和16KD,分析其结果。结果：407例结核病患者中共275例结核抗体阳性，3269例非结核病例547例阳性，结核蛋白芯片检测的
2、灵敏度67.56%,特异度83.27%O对222例患者的治疗后抗体动态观察，开始治疗后每隔3个月抗体阳性人数未逐渐下降。结论：结核蛋白芯片是诊断结核病的较有效方法，具有特异性好、快速方便等优点，对结核病快速辅助诊断有积极作用。尤其对肺结核快速辅助诊断有积极作用，但在淋巴结核、结核性胸膜炎中阳性率偏低，敏感性稍差。对结核病的疗效监测无实用价值。关键词结核分枝杆菌蛋白芯片抗体ThevalueoftuberculosisproteinchipdetectionindiagnosisandtreatmentobservetionoftuberculosisWuYougen,
3、LuoJuhua,LiuHongbing,YangXingping,WangJun,ZhangLiTheSixthPeople，sHospitalofPanzhihuaCity,Sichuan617023FoundationitemPanzhihuaresearchanddevelopmentofAppliedTechnologyProject(ProjectNumber:2013CY-S-16-10)AbstractObjective：Toinvestigatethevalueoftuberculosisproteinchipdetectionindiagnosi
4、sandtreatmentobservationoftuberculosis.Methods:3676casesweregivendetectionofserumantiMycobacteriumtuberculosisantibodybytheproteinchipsystem407casesoftuberculosisand3269casesofnontuberculosis・WeUsedtheproteinchipsystemtodetecteof5componentsinmycobacteriumtuberculosis,respectivelywasESA
5、T-6,CFP10,LAM,38KDand16KD,andanalyzedtheresuIts.ResuIts：In407patientswithtuberculosis,275casesoftuberculosisantibodypositive,in3269casesofnontuberculosis,547casesoftuberculosisoritibodypositive,thesensitivityoftuberculosisproteinchipwas67.56%,andthespecificitywas83.27%.Inthedynamicobse
6、rvationonchangesofanti-tuberculosisantibodyin222patients,itwasfoundthatthenumberofthepatientswithpositivereactiondidnotgraduallydecreaseevery3monthsaftertreatment.Conclusion:Tuberculosisproteinchipisausefulandeffectivemethodfordiagnosisoftuberculosis,alsohavetheadvantagesofgoodspecific
7、ity,rapidandconvenient，andplayapositiveroleinrapiddiagnosisoftuberculosis,especiallyforthepulmonarytuberculosis.Butitislesssensitiveforlymphtuberculosisandpleurisy,andcannotmonitorthetreatmenteffectsoftuberculosis.KeywordsMycobacteriumtuberculosis；Proteinchip；Antibody结核病是结核分枝杆菌（MTB）感
