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1、提要目的：本研究采用隔药灸脐法治疗原发性痛经，以健康受试者为对照，观察治疗前后血浆及尿液的代谢产物谱，找出潜在的生物标记物，推导相关代谢通路，借此探明隔药灸脐法治疗原发性痛经效应机理所在。方法：选取原发性痛经患者10例，正常对照组10例，通过检测患者血液、尿液等的代谢产物谱，寻找其潜在的生物标记物，推导相关代谢通路。结果：隔药灸脐法治疗原发性痛经的代谢产物谱发生了显著变化，其主要表现为：皮质酮、羟脯氨酸、亮氨酸、脱氧皮质酮及苯甲酸、二氢神经鞘氨醇，这些代谢物涉及到体内类固醇激素、一氧化氮、神经递质代谢及氨基酸代谢等过程。结论：隔药灸脐法治疗原发性痛经的代谢
2、组学机制主要是通过调整原发性痛经患者异常的生殖内分泌激素水平，改善其神经、免疫、内分泌网络状况，从而减轻痛经的疼痛程度并改善其伴随症状。关键词隔药灸脐法；原发性痛经；代谢组学TheStudyofMetabonomicsofUmbilicalMoxibustionwithHerbalMedicineonPrimaryDysmenorrhealSyndromeSpeciality:Acupuncture,MoxibustionandMassageAuthor:YuXiaojingTutor:GaoShuzhongAbstractObjective:Bydete
3、ctingmetabolicspectrumofpatients`bloodandurea,tofindoutpotentialbiologicalmarkerandtrytoderiverelatedmetabolicpathwayofumbilicalmoxibustiononprimarydysmenorrhealsyndrome,andtotrytofindoutthemechanismofumbilicalmoxibustiononprimarydysmenorrhealsyndrome.Methods:10primarydysmenorrhea
4、lpatientswererandomlyselectedintreatinggroupand10healthyfemaleincontrolgroup.Bydetectingmetabolicspectrumofpatients`bloodandurea,tofindoutpotentialbiologicalmarkeranddeducerelatedmetabolicpathwayofumbilicalmoxibustiononprimarydysmenorrhealsyndrome.Results:Themetabolismspectrumofpa
5、tientswithprimarydysmenorrhealsyndromehadsignificantlychanged.Thesubstanceschangedwerecorticosterone,hydroxyproline,LeucineandDeoxycorticosterone,2-Methylbenzylbenzoate,Pidolicacid,Ethylhomovanillate,p-Coumaricacid,andPiperidineandSphinganine.ThesemetabolitesinvolvedSteroidhormone
6、biosynthesis,nitricoxide,neurotransmittersmetabolism,andaminoacidmetabolismprocess.Conclusion:Themetabolicmechanismsofumbilicalmoxibustiononprimary,dysmenorrhealsyndromearetoadjustpatientswithprimarydysmenorrheaabnormalreproductiveendocrinehormonelevel,toimprovetheirnervous,immune
7、,endocrinenetworkstatustoreducepainandtoimproveconcomitantsymptomsofprimarydymenorrhea.Keywordsumbilicalmoxibustionwithherbalmedicine;primarydysmenorrhea;metabonomics目录引言...............................................................................................................
8、................1资料与方法...........
