复合纤维蛋白胶磷酸钙在大鼠尾椎中促进腔隙性骨缺损修复的能力

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1、广州医学院硕士学位论文复合纤维蛋白胶磷酸钙在大鼠尾椎中促进腔隙性骨缺损修复的能力Toassesstheabilityofpromotingbonedefectreconstructionofcalciumphosphatecementwithfibringlueforcavitarybonedefectincoccyxofrat学科专业：外科学研究方向：脊柱外科硕士学位研究生：莫世奋导师：李健教授广州医学院·广州2012年5月目录英文缩略词表„„„„„„„„„„„„„„„„„„„„„„„„„„1中文摘要„

2、„„„„„„„„„„„„„„„„„„„„„„„„„„„2英文摘要„„„„„„„„„„„„„„„„„„„„„„„„„„„„4前言„„„„„„„„„„„„„„„„„„„„„„„„„„„„6材料与方法„„„„„„„„„„„„„„„„„„„„„„„„„„„15实验结果„„„„„„„„„„„„„„„„„„„„„„„„„„„„19讨论„„„„„„„„„„„„„„„„„„„„„„„„„„„„30结论„„„„„„„„„„„„„„„„„„„„„„„„„„„„34参考文献„„„„„„„„„„„„„„„„„„„„„„„„„„„

3、„35综述一经皮椎体强化治疗骨质疏松性椎体压缩性骨折新进展„„„„„37综述二磷酸钙骨水泥研发新进展„„„„„„„„„„„„„„„„„52附录在读期间发表的论文„„„„„„„„„„„„„„„„„„„64致谢„„„„„„„„„„„„„„„„„„„„„„„„„„„„„65学位论文原创性声明„„„„„„„„„„„„„„„„„„„„„„„66学位论文知识产权权属声明„„„„„„„„„„„„„„„„„„„„66广州医学院硕士学位论文复合纤维蛋白胶磷酸钙在大鼠尾椎中促进腔隙性骨缺损修复的能力英文缩略词表英文缩写英文全

4、拼中文全称BCEbonecementextravasation骨水泥渗漏BDFbonedefectfiller骨缺损填充材料BMAbonemicro-architecture骨微结构BMDbonemineraldensity骨密度BTEbonetissueengineering骨组织工程学CBDcavitarybonedefect腔隙性骨缺损CPCcalciumphosphatecement磷酸钙骨水泥CPC/FGcalciumphosphatecement复合纤维蛋白胶磷酸钙withfibringlue

5、DBMdecalcifiedbonematrix脱钙骨基质EBFectopicboneformation异位骨化FGFibringlue纤维蛋白胶HAhydroxyapatite羟基磷灰石MMAmethylmethacrylate甲基丙烯酸单体MSCmesenchymalstemcell骨髓干细胞OVCFosteoporoticvertebral骨质疏松性椎体compressivefracrture压缩性骨折PKPpercutaneouskyphoplasty经皮后凸成形术PMMApolymethylme

6、thacrylate聚甲基丙烯酸甲酯PVApercutaneousvertebral经皮椎体强化术augmentationPVPpercutaneousvertebroplasty经皮椎体成形术SBDsegmentalbonedefect节段性骨缺损TCPtricalciumphosphate三磷酸钙1广州医学院硕士学位论文复合纤维蛋白胶磷酸钙在大鼠尾椎中促进腔隙性骨缺损修复的能力复合纤维蛋白胶磷酸钙在大鼠尾椎中促进腔隙性骨缺损修复的能力硕士研究生：莫世奋导师：李健教授中文摘要：目的：在骨质疏松大鼠或骨量

7、正常大鼠尾椎腔隙性骨缺损（CBD）中,通过比较复合纤维蛋白胶磷酸钙（CPC/FG）和单纯磷酸钙（CPC）促进骨缺损修复的能力来验证：1、在骨量正常大鼠中，复合纤维蛋白胶（FG）成孔原改良后的CPC是否较单纯的CPC具有更强的骨缺损修复能力；2、在骨质疏松大鼠中，CPC/FG是否较单纯的CPC具有更强的骨缺损修复能力。方法：取36只8周龄重约200g雌性SD大鼠随机平分成骨质疏松组（OVX）和骨量正常组(NL)。先对18只OVX组大鼠行卵巢摘除后予低钙饲料饲养3个月建立骨质疏松模型，NL组18只大鼠在同样环

8、境下普通饲料饲养3个月。把NL组的18只大鼠随机平分成NL实验亚组（NI）和NL全阴对照亚组（NN）；把OVX组的18只大鼠也随机平分为OVX实验亚组（OI）和OVX全阴对照亚组（ON）。对四个亚组共36只大鼠用穿刺针于第一尾椎（Co1）和第二尾椎（Co2）钻孔建立腔隙性骨缺损（CBD）。对NI亚组和OI亚组共18只大鼠分别于第一尾椎骨缺损部位填充CPC（NI-Co1和OI-Co1）和第二尾椎骨缺损部位填充CPC/FG(NI-