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ID:32840639
大小:4.28 MB
页数:57页
时间:2019-02-16
《不同剂量右美托咪定复合舒芬太尼在子宫全切术后的镇痛效果》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、郑州大学硕士学位论文不同剂量右美托咪定复合舒芬太尼在子宫全切术后的镇痛效果姓名:赵蕾申请学位级别:硕士专业:麻醉学指导教师:董铁立201205摘要不同剂量右美托咪定复合舒芬太尼在子宫全切术后的镇痛效果研究生赵蕾导师董铁立教授郑州大学第二临床学院麻醉科河南郑州450014目的观察不同剂量盐酸右美托咪定复合舒芬太尼在全麻下行腹式子宫全切术后患者自控静脉镇痛中的应用效果。方法选择本院2011年7月.2012年1月择期全身静脉麻醉下腹式子宫全切手术、ASA分级I或II级、年龄30.60岁、BMI在18--23kg/m2术后自愿行静脉自控镇痛泵治疗
2、的患者80例,随机分为四组:舒芬太尼组(S组)和三组不同剂量盐酸右美托咪啶+舒芬太尼组(Di、D2、D3组)。S组为舒芬太尼0.04斗g/kg·h,Di、132、D3组分别为盐酸右美托咪啶(O.08、O.09、0.10)ug/kg.h+舒芬太尼0.02I_tg/kg·h,于手术结束即刻行患者自控静脉镇痛。记录术后lh、6h、12h、24h、48h五个时间点患者的镇痛评分(采用静息VAS评分法)和镇静评分(采NRamsay镇静评分法):PCA有效按压次数;血压、心率、脉搏氧饱和度、呼吸频率的变化情况:不良反应及术后48h镇痛效果总体评价。结
3、果镇静效果比较:与S组相比,D2、D3组在术后6h、12hVAS评分降低,差异有统计学意义(P<0.05),DI组在术后lh、6hVAS评分增高(P0.05),S组、D2组和D3组均能达到目标镇痛水平,各时间点VAS均摘要铒分(P>O.05):镇静效果比较:与S组相比,Dl组在术后1hRamsay评分降低(P4、4h四个时间点的Ramsay评分均增高(P0.05);D2组术后1-48h血流动力学更加平稳,四组呼吸频率变化差异无统计学意义(P>0.05);Dl、D2、D3组不良反应发生率明显降低(P5、tEfficacyofDifferentDosesofDexmedetomidineAssistantwithSufentanilOHthePCIAafterHysterectomyPostgraduate:LeiZhaoSupervisor:Pro。TieliDongDepartmentofAnesthesiology,theSecondClinicalCollegeofZhengzhouUniversity.Zhengzhou,Henan450014,ChinaobjectivesToevaluatetheeffectsofdiffe6、rentdosesofdexrnedetomidineassistantwithsufentanilontheefficacyofpatient-controlledintravenousanalgesiaafterhysterectomy.MethodsEiglltypatients,whowereVoluntarytouseself-controlledintravenousanalgesiapumpinthetreatmentofelectivegeneralanesthesiaabdominaltypeofoperationoft7、otalhysterectomy,agedfrom30to60yearsoldandASAgradeIorII,cameadmiredtoourhospitalfromJuly201ltoJanuary2012andwererandomlydividedinto4groups:groupSsufentanilandthreegroupsofDl,D2andD3.Differentdosesofdexmedetomidineplussufentanii.GroupSissufentanilO.04I-tg/kg‘h,GroupDt,De、D8、3aredexmedetomidine(O.08、0.09、0.10)pg·kg--1.h-‘plussufentanilO.021ag’kg一·h-’separately,PCIAwasst
4、4h四个时间点的Ramsay评分均增高(P0.05);D2组术后1-48h血流动力学更加平稳,四组呼吸频率变化差异无统计学意义(P>0.05);Dl、D2、D3组不良反应发生率明显降低(P5、tEfficacyofDifferentDosesofDexmedetomidineAssistantwithSufentanilOHthePCIAafterHysterectomyPostgraduate:LeiZhaoSupervisor:Pro。TieliDongDepartmentofAnesthesiology,theSecondClinicalCollegeofZhengzhouUniversity.Zhengzhou,Henan450014,ChinaobjectivesToevaluatetheeffectsofdiffe6、rentdosesofdexrnedetomidineassistantwithsufentanilontheefficacyofpatient-controlledintravenousanalgesiaafterhysterectomy.MethodsEiglltypatients,whowereVoluntarytouseself-controlledintravenousanalgesiapumpinthetreatmentofelectivegeneralanesthesiaabdominaltypeofoperationoft7、otalhysterectomy,agedfrom30to60yearsoldandASAgradeIorII,cameadmiredtoourhospitalfromJuly201ltoJanuary2012andwererandomlydividedinto4groups:groupSsufentanilandthreegroupsofDl,D2andD3.Differentdosesofdexmedetomidineplussufentanii.GroupSissufentanilO.04I-tg/kg‘h,GroupDt,De、D8、3aredexmedetomidine(O.08、0.09、0.10)pg·kg--1.h-‘plussufentanilO.021ag’kg一·h-’separately,PCIAwasst
5、tEfficacyofDifferentDosesofDexmedetomidineAssistantwithSufentanilOHthePCIAafterHysterectomyPostgraduate:LeiZhaoSupervisor:Pro。TieliDongDepartmentofAnesthesiology,theSecondClinicalCollegeofZhengzhouUniversity.Zhengzhou,Henan450014,ChinaobjectivesToevaluatetheeffectsofdiffe
6、rentdosesofdexrnedetomidineassistantwithsufentanilontheefficacyofpatient-controlledintravenousanalgesiaafterhysterectomy.MethodsEiglltypatients,whowereVoluntarytouseself-controlledintravenousanalgesiapumpinthetreatmentofelectivegeneralanesthesiaabdominaltypeofoperationoft
7、otalhysterectomy,agedfrom30to60yearsoldandASAgradeIorII,cameadmiredtoourhospitalfromJuly201ltoJanuary2012andwererandomlydividedinto4groups:groupSsufentanilandthreegroupsofDl,D2andD3.Differentdosesofdexmedetomidineplussufentanii.GroupSissufentanilO.04I-tg/kg‘h,GroupDt,De、D
8、3aredexmedetomidine(O.08、0.09、0.10)pg·kg--1.h-‘plussufentanilO.021ag’kg一·h-’separately,PCIAwasst
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