rasgrp1在湿疹发病中的作用及机制的研究

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1、分类号学号D200978191学校代码10487密级博士学位论文RasGRP1在湿疹发病中的作用及机制的研究学位申请人：杨柳学科专业：皮肤病与性病学指导教师：涂亚庭答辩日期：2012.5AdissertationsubmittedtoHuazhongUniversityofScienceandTechnologyfortheDegreeofDoctorofMedicineStudyontheroleofRasGRP1inthepathogenesisofeczemaandmechanismsDr.Candidate:YangLiuMajor:Dermatology

2、andvenereologySupervisor:Prof.TuYatingHuazhongUniversityofScience&TechnologyWuhan430074,P.R.ChinaMay,2012独创性声明本人郑重声明，本学位论文是本人在导师指导下进行的研究工作及取得的研究成果的总结。尽我所知，除文中已经标明引用的内容外，本论文不包含任何其他个人或集体已经发表或撰写过的研究成果。对本文的研究做出贡献的个人和集体，均已在文中以明确方式标明。本人完全意识到本人将承担本声明引起的一切法律后果。学位论文作者签名：日期：年月日学位论文版权使用授权书本学位论文作

3、者完全了解学校有关保留、使用学位论文的规定，即：学校有权保留并向国家有关部门或机构送交论文的复印件和电子版，允许论文被查阅和借阅。本人授权华中科技大学可以将本学位论文的全部或部分内容编入有关数据库进行检索，可以采用影印、缩印或扫描等复制手段保存和汇编本学位论文。保密□，在_____年解密后适用本授权书。本论文属于不保密□。（请在以上方框内打“√”）学位论文作者签名：指导教师签名：日期：年月日日期：年月日目录英文缩略词···········································································

4、·································1中文摘要················································································································3英文摘要················································································································7前言···············

5、·······························································································12仪器与材料··········································································································14第一部分RasGRP1在湿疹患者外周血单个核细胞及T细胞中的表达及意义········································

6、·························································19第二部分地塞米松对湿疹患者T细胞中RasGRP1表达的作用及意义··········································································································34第三部分构建含有H-RasGRP1-shRNA的慢病毒载体及其对T细胞的干扰效应··············································

7、·················································46小结··············································································································66综述··············································································································67参考文献··

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