功能性膜材料及其的构建脂质体作为抗肿瘤药物载体地地研究

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1、目录中文摘要···········································································1英文摘要···········································································3主要缩略语注释表·····························································6引言·························································

2、···················8正文··········································································10第一部分功能性膜材料的合成及表征······························101实验材料和仪器·····························································102实验方法·····································································

3、····112.1GALA-SA的合成及表征·····················································112.2Folate-Cys的合成及表征······················································132.3Folate-PEG3500-DSPE的合成及表2征·········································152.4MCP多肽的合成及表征·····················································

4、·163结果与讨论······································································173.1GALA-SA的合成与表征····················································173.2Folate-Cys的合成与表征·····················································193.3Folate-PEG3500-DSPE的合成及纯度检测···································2

5、03.4MCP的合成与表征····························································214小结··············································································22第二部分Folate-PEG-脂质体递药系统的构建及表征························231材料与仪器······································································232

6、实验方法·········································································242.1脂质体递药系统的构建·······················································242.2Folate-PEG-脂质体/阿霉素（FA-P-LS/DOX）的构建及表3征··············262.3Folate-PEG-脂质体/FAM（FA-P-LS/FAM）的构建及表征·················282.4GALA-脂质体（G-LS）的构建及pH敏感性

7、评价···························283结果与讨论······································································293.1制备方法的比较······························································293.2Folate-PEG-脂质体/阿霉素（FA-P-LS/DOX）的表征·······················313.3Folate