b淋巴刺激因子与慢性丙型肝炎自身免疫现象关系的研究

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1、博士学位论文英文摘要ABSTRACTBackground：Themechanismsorpathophysiologythatleadtopresenceofauto—antibodiesinpartofchronichepatitisCpatientsarenotyetfullyunderstood．Cross-reactiveimmuneresponsebetweenahostantigen(GOR)andanaminoacidsequenceofHCVcoreantigenmaybethecauseoflowti

2、terofautoantibodybutnotcommensuratestheimmunedisordersinHCVpatients．HostfactorsseemtobeinvolvedintheHCVassociatedautoimmunity．Anotherresearchshowsthat50％一90％patientsofMCanditsassociatedglomerulonephritisareHCV—RNApositive．AntibodytoLiverKidneyMicrosomaltype1(LKM

3、OwasdetectedinHCVinfectedpatients，whichisasignofautoimmunehepatitis．LiverhistologicalchangesofHCVinfectedpatientsaresimilartothatofautoimmunehepatitis．ResearchersspeculatethatautoimmunitymayplayaroleinthemechanismofHCVpathogenesis．ThepresenceofautoantibodyinHCVp

4、atientsmaybeduetoHCVinducedimmunedisorders．objective：Immunecellsareinfectedbecauseofpan-tropismofHCV．SomeresearchshowT-cellsubgroupsarechangedandthebalanceoftheimmunitysystemisbrokeninHCVinfectedpatients．ThechangesinimmunefunctionofBcellanditssubsetsarenotyetkno

5、wn．Tothisend，serumBLySlevels，expressionofBLyS—mRNAinPBMCandtheV博士学位论文英文摘要changesofBcellsubsetswereinvestigatedinautoantibody-positiveHCVpatientsandcomparedwithautoantibody—negativeHCVpatientsandhealthydonorS．ThepurposeofthisresearchistoinvestigatetherelationofHC

6、Vinfectionandautoimmunity，deeplyunderstandthemechanismofHCVpathogenesisandprovidesupportforpatient-focusedtreatment．Methods：(1)．ResearchsubjectsweredividedintohealthycontrolgroupandHCV—group，whichwasfurtherdividedintopositiveauto—antibodysubgroupandnegative—auto

7、antibodysubgroup．(2)SerumBLySlevelsweretestedwithELISAassay；ConventionalmethodswereusedfordetectionofimmunoglobulinandRF；SerumLaboratoryMarkersofLiverFibrosisweredetectedbyradioimmunoassay；HCV-positivepatientsweretestedforcryoglobulinwithqualitativedetectionmeth

8、od．(3)．27HCV—RNApositivepatientsfellintotwogroupsaccordingtotheserumBLySlevels(elevatedandnormal)，andweretreatedwithinterferon-aplusribavirincombinationtherapy．Serums