奈必洛尔对肺高血流致大鼠肺动脉重构的影响

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1、英文摘要group．Comparedwiththeshamgroup，baseeXCeSS(Beb)inshuntgroupwasslightlylower，butthedifferenceshavenostatisticalsignificance．4Intheshamgroup，Acetylcholine(10‘8"-。10。5mol／L)callreducethetensionofPulmonaryarterialringswerepre—contractedbyPhenylephrine(10。0mol／L、i

2、naconcentration—dependencemanner．Inshuntlgroup，theroleonreducingthePulmonaryarteryringtensionwhichplayedbyAcetylcholine(10一～10。5mol／L)tendstodecline，ataconcentrationof10弓mol／Lacetylcholine，thepulmonaryarteryringtensionWaSsignificantlyhigherthantheshamgroup(p

3、01)，whichshowedthattheratpulmonaryarterialendothelialdamagesintheshuntgroup．UndertheCaptoprilandnebivololintervention，thevasorelaxanteffectofpulmonaryarterialringsinducedbyacetylcholine(10。8～10’5mol／L)wassignificantlystrongerthanthatinshuntgroup(p<0．05orP<0．01or

4、P<0．001)，whichexplainsthatcaptoprilandnebivololreallyplayaroleonprotectingtheimpairedpulmonaryvascularendothelial．Inaddition，captoprilhasbettervasorelaxanteffectthannebivol01．5Comparedwiththerats(1．38士0．07)inshuntlgroup，theexpressionofPCNAinlungtissueofratsincap

5、t+shunt(1．16-4-0．04)andneb+shunt(1．214-0．05)groupstendstOdecline，butthedifferenceshavenostatisticalsignificance．6Undertheopticalmicroscope，inshuntgroup，thepulmonarymusculararterywassignificantlyincreaced，RMTofsmallmusculararteriesandmiddlemusculararteriesappeare

6、dobviousthickening，pulmonaryarterialstructureremodelingoftheratsincapt+shuntandneb+shuntgroupshavesignificantlyameliorated；Intheshuntgroup，observedunderthetransmissionelectronmicroscope，theinternalelasticlamina(IEL)ofpulmonaryarteryarrangedindisorderandfracture，

7、smoothmusclecellsincreasingundertheinternalelasticmembrane，smoothmusclecellproliferationhappened；Incapt+shuntandneb+shuntgroups，pulmonaryelasticmembranehasbasicintegrity，regulararrangement，smoothmusclecellsinshuttle—shape，whilethevascularendothelialcellsseemmild

8、edema．Conclusion：Nebivol01andCaptoprilalleviatedratpulmonaryvascular5remodelinginducedbyhighpulmonarybloodflow，andreversedrightventricularhypertrophy，andwiththeprotec