雌激素调控大鼠心肌细胞l型钙通道表达作用及其机制

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1、ADissertationSubmittedinPartialFulfillmentoftheRequirementsfortheDegreeofMasterofEngineeringTheregulationandmechanismofestrogenonL-typecalciumchannelinratcardiomyocytesCandidate:MaoXiaofangMajor:PharmacologySupervisor:Prof.JinSiHuazhongUniversityofScience&TechnologyWuhan430074,P.R.ChinaDecember,

2、2012独创性声明本人声明所呈交的学位论文是我个人在导师指导下进行的研究工作及取得的研究成果。尽我所知，除文中已经标明引用的内容外，本论文不包含任何其他个人或集体已经发表或撰写过的研究成果。对本文的研究做出贡献的个人和集体，均已在文中以明确方式标明。本人完全意识到本声明的法律结果由本人承担。学位论文作者签名：日期：年月日学位论文版权使用授权书本学位论文作者完全了解学校有关保留、使用学位论文的规定，即：学校有权保留并向国家有关部门或机构送交论文的复印件和电子版，允许论文被查阅和借阅。本人授权华中科技大学可以将本学位论文的全部或部分内容编入有关数据库进行检索，可以采用影印、缩印或扫描等复制

3、手段保存和汇编本学位论文。保密□，在年解密后适用本授权书。本论文属于不保密□。（请在以上方框内打“√”）学位论文作者签名：指导教师签名：日期：年月日日期：年月日目录主要文缩略词表················································1中文摘要······················································2英文摘要······················································5前言······································

4、················8材料和方法····················································11实验结果······················································26讨论·······················································38全文结论·······················································40综述······································

5、·················45工作小结······················································66致谢······················································67华中科技大学硕士学位论文主要缩略词表（Abbreviation）英文缩写英文全称中文名称APactionpotential动作电位APDactionpotentialduration动作电位时程Ca-LL-typecalciumchannelL型钙通道cAMPcyclicadenosinemonophosphate环

6、腺苷酸cAMP反应元件结合蛋CREBcAMPresponseelementbindingprotein白CREBdecoyCREB-decoyoligonucleotideCREB圈套寡核苷酸ODNE217β-estradoil17β-雌二醇雌激素-雌激素受体复合E2-ERestrogen-estrogenreceptorcomplex物EADearlyafterdepolarization早后除极ERestrogenreceptor雌激素受体EREestrogenresponseelement雌激素反应元件ICa-LL-typecalciumcurrentL型钙电流+rapidcom

7、ponentofdelayedrectifierK延迟整流钾电流快速成IKrcurrent分LQTslongQTsyndrome长QT综合征MAPKmitogen-activatedproteinkinase丝裂原活化蛋白激酶NCXsodiumcalciumexchange钠钙交换体NFATnuclearfactorofactivatedTcells活化T细胞核因子NF-κBnucleartranscriptionfactor-κB核转录因子-