应用组织封闭剂经支气管镜肺减容术的动物实验研究

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1、第三军医火学硕士学位论文LVRS．Refinementandapplicationofthesetechniqueswilla110wpatientswithemphysemaandtheirphysiciansandsurgeonstochoosefromanumberofViableoptionsforlungvolumereduction．ItmayproVetobetheexistingcasethatValVeinsertionwillbetheappropriatetherapywhenthereisheterogeneousdiseaseandatargetl

2、obecanbeidentified．Inhomogeneousdisease，withintralobarcoUateralVentilationbeingmore1ikely，theairwaybypassapproachmayproVetobepreferable．Onlyanimaldataaboutbronchoscopicinjectionofp01ymersareavailableatpresentanditremainsunclearwhetheritwillbepossibletoapplythistechniquetohumans．Itispossibl

3、ethatthistechniquecouldbeusedinbothtypesdisease．Theapproachofbronchoscopici11jectionofpolymershasbeentofindtissueengineeringapproachesthatwillproduce1ungVolumereductionbycausingscarringintargetareasofthelung．OnlyanimaldataareaVail百bleatpresentanditremainsunclearwhetheritwillbepossibletoapp

4、lythistechniquetohumans．Ingenitoeta1．suggestedcollapsingtargetregionsofthelungsusingaproceduresimilartobronchoalVeolar1aVage．ThelavageinVolVescontrolledremoValofbronchialepithelialliningcellswithawashoutsolutionandthedeploymentofafibrinhydrogel．InasheepmodelofemphysemathisprocedureachieVed

5、scartissuefbrmation，whichreplacedhyperinnatedlung，reducedoveralllungVolume，andimproVedrespiratoryfunctionsafelyandconsistently．Inourstudy，weobserVethelungshapeofcrossbreeddogs，inVestigatesthepossibilityoflungV01umereductionwithbronchoscope，explorethemethodandtechniqueofBLVR，observetheeff色c

6、tofbronchoscopiclungVolumereductionusingfibrin—basedglue，investigatethepossibilityandsafe，offerexperimentaleVidenceoftheminimallyinVasiVetechniquesforthetreatmentofemphysema．Themaincontentsofourstudyareasfollows：1．TbobservethelungshapeofcrossbreeddogsandinVestigatethepossibilityoflungvolum

7、ereductionwithbrobronchoscope1)TbinVestigategeneralstateofhealth，atbaseline，atoperationofBLVR，atrecoVeryafterBLVR，includingheartrate，respiratoryrate，oxygensaturation．2)Tbobservethelungshapeofcrossbreeddogsincludingthe1engthoftracheabybrobronchoscope．3)Tbobserv