辅助内分泌治疗对i期子宫内膜癌疗效的临床观察

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1、维普资讯http://www.cqvip.com·824·中国实用妇科与产科杂志2006年l1月第22卷第l1期论著文章编号：1005—2216(2006)11—0824—04辅助内分泌治疗对I期子宫内膜癌疗效的临床观察王志启，王建六，魏丽惠【摘要】目的研究辅助内分泌治疗对I期子宫内膜癌患者预后的影响。方法选取1992-01—2002—12共l】年间我院诊治I期子宫内膜癌患者105例进行回顾性研究。结果内分泌治疗组和对照组无瘤生存及总生存情况比较，差异无统计学意义(P：0．2639，P=0．2066)。内分泌治疗

2、l2个月的患者则为0例，差异有统计学意义(P=0．035)；二者因癌死亡患者分别为8例(11．8％)和0例，差异无统计学意义(P：0．074)；二者无瘤生存及总生存情况的K—M曲线差异均有统计学意义(P=0．0163，P=0．0396)。多因素分析提示肿瘤细胞分化程度、患者年龄及内分泌治疗时间对I期子宫内膜癌患者的无瘤生存及总存活率有一定影响。结论辅助内分泌治疗l2个月或以上，可在一定程度上改善I期子宫内膜癌患者的预后。【关键词】子宫内膜癌；辅助内分泌治疗；孕激素；预后中图分类号：R71文献标志码：AAclinicalanalysisoftheefectsofadjuvantendo

3、crinetherapyforstageIendometrialcarcinoma．Zhiqi，WangJianliu，WeiLihui．CenterofGynecologicOncology，PekingUniversityPeople"sHospital，Bering100044，ChinaAbstract0bjectiveToanalyzetheeffectsofadjuvantendocrinetherapyontheprognosisofstageIendometrialcarci—noma．MethodsAretrospectivestudywascarriedouton

4、105casesofstageIendometrialcarcinomawhowereadmittedtoourdepartmentfromJan．1992toDec．2002．Thepatientsweredividedintotheendocrinetherapygroup(54cases，51．4％)andthecontrolgroup(51cases，48．6％)．ResultsTheratesofrecurrenceandmetastasisintheendocrinetherapygroupandthecontrolwere5．6％and13．7％respectively

5、．Andtherewasnoobviousdiferenceonthedeathfromtheendometrialcarcinomarateeither，whichwere3．7％and11．8％respectively，P=0．274，P=0．153；sodidthesurvivalcurveofthem(P=0．2639，P=0．2066respectively)．Theratesofrecurrenceandmetastasisofthecontrolandthepatientsreceivingadjuvantendocrinetherapylessthan12months

6、was14．7％．Butitwaszeroforthepatientsreceiv—ingadjuvantendocrinetherapyreachingtoorlongerthan12months．Therewasstatisticaldifferencebetweenthem(P=0．035)．Thepatientsdiedfromendometrialcarcinomawere8／68and0／37，respectively．Therewasborderlinedifferencestatistically(P=0．074)．Thesurvivalcurveofthemdiff

7、eredmuch(P=0．0163，P：0．0396)．Multivariateanalysisshowedthatthetumorcelldifferentiation，ageandendocrinetherapydurationaffectedthetumorfreesurvivalandtotalsurvivalofstageIendometrialcarcinoma．ConclusionsAdjuvantendocrinetherapynoless