健脑益血合剂的制剂工艺及质量标准研究

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1、万方数据StudyonPreparationProcedureandQualityStandardof3iannaoYixueMixtureABSTRACTobjective：“JiannaoYixuesyrups”isfromclinicalexperienceside．itisnotconvenienttotakeformostpatientsbecauseoflargedosageandlargecontentofsucrose．Thenewdosageformisbasedonthatmixturehas

2、largedispersionanditisliquidpreparationwhichcouldbequicklyabsorbed，andthebioavailabilityisquiethigh,SOithasquietarapideffect．Moreover,itisconvenienttotake，storeandcarry,andcanbemadeintothepreparationwithoutsucrose．SothiskindofmixtureCanmeetthedemandoftheclini

3、calpatientsandensurethepreparationofcomprehensiveefficacy．Soitisnecessarytochangesyrupsintomixtureandwehopethatitcanprovidesomecertainguaranteewiththeserelativestudies．Methods：Accordingtothepropertyofchemicalingredientsandthefunctioninthisprescription，usingsi

4、nglefactortestandorthogonalexperimentwithmultifactorevaluationcomprehensively,SOthattheprocesstechnobgyandqualityspecificationofJiannaoYixuemixturewereobtained．(1)Studyonpreparationprocedure：Weconsideredtheextractmethodofessentialoilinthecomplexprescriptionby

5、usingsinglefactorinvestigation，andbasedonthisyieldofessentialoil,wecouldoptimizethebeststeamdistillationprocessparameteroftheextraction．Usingtraditionalextractingmethodofaddingthewatertodecorateherbs，thethreemainlycheckingfactorsofquantityofvolume，extractingt

6、imeandextractingtimeswerestudiedthroughusingmulti-factororthogonalexperimentdesignwiththecontentofLoganinandChlorogenicacidasindex，andthenweascertainedthebestextractionprocess．Throughusingthemethodofsinglefactortest,万方数据wkhthefiltration，centrifugation，50％alco

7、hol,60％alcohol,70％alcoholandsoon．asthefactorsandthecontentoftheactiveingredientLoganinandChlorogenicacidasindex，thenthebestpurificationtechnologyofthepreparationwasstudiedanddetermined．ThesingleherbuncariaWasextractedbyethanoLWeconsideredthecontentoftheactive

8、ingredientIsorhynchophy‘llineastheindexbyorthogonalexperimentdesi印，andwecoulddeterminethebestparameterofalcoholextractiontechnology．Atlast，weoptimizedthepreparationprocess吨conditionsandde