tlr2单克隆抗体影响大鼠角膜移植排斥反应的实验研究

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1、万方数据硕士学位论文Effectofanti··TLR2monoclonalantibodyonratcornealtransplantationrejectionBackgroundName：ZhengYan·huaSupervisor：BaiLangABSTRACTCornealallograftisoneofthemostsuccessfulsolidorgantransplantation，howeverrejectionafterthetransplantationisthemajorcauseofthefailure．

2、Studieshaveshownthat：comealallograftrejectionisamultifactorparticipated，extremelyintricated，andhighlycontroledprocess．Afterthetransplantation，asthepresentingoftheantigen，CD4+Tcellactivate，leadingtothedifferentiationofThlandsecretionofIL-2、IFN-YandTNF-O【whoCanmediatedd

3、estructiveDTH，meyplayaleadingroleincornealallograftrejection．Kuffovabelievesthatattheearlystageofthetransplantationimmunereactionsmanifestasinflammation．Hollandalsoobservedthatintheearlydaysofthecomealrejectionexistnonspecificinflammation：Tcellsandmacrophagesgathereda

4、roundtheincisionandsutures，cornealgr世arethickened．Hollandemphasizedthattherejectionofthecellularimmuneresponseisdifferentfromtheisograftofcellularimmunity，nonspecific万方数据ABSTRACTinflammationaroundtheearlypostoperativeincisionandsuturesisanimportantfactorofthegrowthofn

5、ewbloodvesselswhichwereinducedbydonordamagedendothelialcell．Ininflammatoryplantbed，thedendriticcellscomefromthedonortransitionstothehost。SnecklymphnodestoactivateTcellsdirectlyinducerejection．Thepathologicalchangesoftheacuterejectionincorneaallografthavetwomaincharact

6、eristics：thecornealstromallayerinfiltratedwithinflammatorycellsandneovascularization．Comealstromainflammatoryinfiltrationwasbasedonmonocytes，andlymphocytes、plasmacyte、neutrophilsandSOon．Theinflammationmayledtothedisappearingoftheadvantageasanimmuneamnestyregionalincom

7、ea，rejectionoccurredearlyandsevere，evenimmuneinhibitorscannotregulate．AlthoughtheinitialrejectionwascausedbytheacquiredimmunesystemofT-lymphocytesinthehost，newevidencesuggeststhattheinnateimmunesystemalsoplaysanimportantrole．Toll-likereceptorswasabridgewhichlinkinnate

8、immunityandacquiredimmune，andToll—likereceptor2(TLR2)Wastheonemostwidelyexpressed、mostlargelyidentifiedofpathogenicmicroorga