lrig1与脑膜瘤增殖关系的研究及意义

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1、堡主堂!!堡壅一一一———————型：兰!!墅ABSTRACTObjectives：WeinvestigatetherelationshipbetweenLRIGlandKi-67inmeningiomasviadetectingtheexpressionofLRlG1andKi-67invariousgradesofmeningiomas，whichmightprovidetheoreticalbasisfortreatmentandprognosisforpatientswithmeningiomasMethods

2、：Westudiedeighty—sevenspecimensdiagnosedasmeningiomasofvarioushistologicaltypesandgradesextractedfrompatientswhounderwentsurgeryfirstlyinthedepartmentofneurosurgeryofthesecondxiangyahospitalofCSUduringtheperiodfromOctober,2009toNovember,2011．Noneofthesepatientsu

3、nderwentbrainoperationsbefore．ElevennormalbrainmeningesspecimensusedasthecontrolgroupwereobtainedfrompatientswithacutecraniocerebralinjurywhounderwentsubtemporaldecompressionduringtheperiodfromApril，2011toNovembe92011Patientsincontrolgroupdidn’thavethehistoryofn

4、eoplasiaAllthesespecimensweredividedintofourgroups：accordingtotheWHOclassificationofbraintumorsin2007，itwerecategorizedintograde1groupwithsixty—eighteases，grade11withelevencasesandgradeliIgroupwitheightcasesandelevenspecimensofnormalbrainmeningesascol_ltrolgroup

5、WesternBlotwasusedtodetecttheexpressionofLRIGlandKi一67inmeningiomasandcontrolgroupResults1ExpressionofLRIGlinthetumorgroupissignificant里堕型塑墨————茎兰塑鐾lowerthanthatinnormalcontrolgroup．Therearestatisticaldifferencesamongvariousgradesofmeningiomasintermsofexpression

6、ofLRIGI．2,TheexpressionofKi一67inthetumol+groupsignificanthigherthanthatinnormalcontrolgroup．TherearestatisticaldifferencesamongvariousgradesofmeningiomasintermsofexpressionofKi．673Inmeningiomas，theexpressionofLRIGIandKi一67wasnegativecorrelated(p<0．05)．Conclusion

7、s1．TheexpressionofLRIGIinmeningiomaswaslowerthanthatinnormalcontrolgroup．Itsexpressiondecreasesalongwiththetumorgrade．2．TheexpressionofKi一67inmeningiomagroupwashigherthanthatinnormalcontrolgroupItsexpressionincreasesalongwiththetumorgrade3．LRIGImayrestrainprolif

8、eimtionofmeningiomas．KEYWORDSLRIGl，Ki一67，prolifeiration，meningiomas型!!!!．一——————————————一旦重目录中文摘要，⋯1英文摘要⋯IIl}ii『言⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯l第一章材料与方法⋯⋯⋯h⋯⋯⋯⋯⋯·3ll实验材料⋯⋯⋯⋯⋯⋯⋯⋯⋯一31．2