hmgb1、ckit2b、mirna206在早期心肌缺血猝死心肌中的表达与心肌干细胞的探讨

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1、大连医科大学硕士学位论文著性差异(P<0．01)，在早期心肌缺血猝死组和心肌梗死猝死组的心肌存在显著性差异(P

2、血猝死组和心肌梗死猝死组除胞核有阳性表达外，其胞浆中也有阳性表达，正常心肌组织心肌细胞胞浆为阴性。HMGBl在心肌梗死组的表达量高于早期心肌缺血猝死组。3．与正常心肌组相比，c．kit+在早期心肌缺血猝死组和心肌梗死猝死组中表达较多，且c．kit+在心肌梗死猝死组中的表达高于早期心肌缺血猝死组。4．与正常心肌组相比，miRNA．206在早期心肌缺血猝死组和心肌梗死猝死组中呈现高表达，且miRNA．206在心肌梗死猝死组的表达高于早期心肌缺血猝死组。5．HMGB1、c．kit+和miRNA．206在

3、早期心肌缺血猝死心肌、心肌梗死猝死心肌中的高表达及HMGBl和C．kit+表达的正相关性可以作为诊断早期心肌缺血猝死法医学鉴定的辅助检查手段。关键词：心源性猝死早期心肌缺血心肌干细胞I删IGBle-kit+miRNA-206大连医科大学硕士学位论文TheproliferationanddifferentiationofCSCsinearlyyocardia’ischemiasuddendeathandthe"LgnificanImyocaralalISCllem11eatlaantllesiRni

4、licancei。nforensicpathologyloreuSICDat010Masterdegreecandidate：LuChenjiaSuperviser：ProfessorLiLianhongBackgroundand0bjectiveMarjor：ForensicMedicine[Abstract]Suddencardiacdeathisoneofthemostcommontypesinsuddendeathcases，causedbycardiacfactorwithorwitho

5、utcardiacdisease．Coronaryheardiseaseisacommoncardiovasculardiseases，myocardialischemiaduetocoronaryarterystenosisandischemicnecrosisofmyocardialcelldamageandevenmyocardialinfarction，whichcanleadtotheoccurrenceofsuddencardiacdeathandmyocardialischemiaw

6、asoneofthecausesofsuddencardiacdeath．Intheprocessofforensicpathologicjustification，focalmyocardialinfarctioncanbediagnosedbygrossormicroscopicobservation．Nevertheless，earlymyocardialinfarctionisusuallytoughtoobservetypicalpathologicalchange，asthemostd

7、ifficultissueinforensicjustification．Somesurveyshavereportedthatearlymyocardialinfarctionormyocardialinfarctioncaninducecardiacstemcells(CSCs)proliferationanddifferentiationinordertorepairinjuredmyocardialcells．CSCsarepluripotentstemcell，whichpossesst

8、heabilityofproliferationanddifferentiationinadultmyocardialtissue．，andCSCshavetheabilityofmyocardialregenerationandrepair．Highmobilitygroupboxprotein1(HMGB1)，asasignaloftissuedamage，playsacriticalroleintheearlyandlateperiodofmyocardialinfarcti