87例胃间质瘤的临床分析

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1、大连医科大学硕士学位论文结论：1、胃间质瘤临床表现无特异性，术前确诊率较低，仍需完善胃间质瘤的检查技术，提高确诊率。2、手术仍是治疗胃间质瘤的首选方案，应尽可能做到完整切除病灶，对于中高危患者，应同时辅以甲磺酸伊马替尼治疗。3、对于术后出现复发或转移的可能性较大的患者，应定期随诊，尤其在术后2年内。即使出现复发、转移，也应积极争取再次手术，同时配合甲磺酸伊马替尼辅助治疗。关键词：胃间质瘤免疫组化伊马替尼预后2大连医科大学硕士学位论文Clinicalanalysisof87PatientswithGastricStromalTumorMasterdegreecandidate：LuK

2、ebinSupervisor：ProfessorTianDayuVice—supervisor：ProfessorHuXiangMajor：GeneralSurgeryAbstractobjecfiveToinvestigatetheclinicalcharacteristics，diagnosis，treatmentandprognosisofdecisionfactorsofgastricstromaltumor．MethodsClinicaldataof87patientswithgastricstromaltumorfromJanuary2008toJanuary2013w

3、ereanalyzed．ResultsThepatientsofGastricstromaltumorhavedifferentclinicalmanifestations，lackofpatientswithtypicalclinicalmanifestmions．Themainclinicalmanifestationwerebloodystools，abdominalpainanddistension．Thediagnosisbeforeoperationismainlydependedongastroscope，CT，MIU，ColorDopplerUltrasoundto

4、findtheplaceholderlesionsinthestomach，butonly12patients(13．7％)achievedpreoperativepathologicaldiagnosis．Thepatientsofhigh—lowrisk，lowrisk，intermediaterisk，andhighriskwas13cases(14．9％)，27cases(31．1％)，25cases(28．7％)，and22cases(25．3％)，respectively．Therearethreekindsofpostoperativepathologytypes，s

5、pindlecelltype(75％)，epithelioidcelltype(17．6％)andmixedtype(7．4％)．Comparedthelevelofriskandthehistologicaltype(accordingtothe贮，贮=0．6786，P>0．05)，therewasnostatisticallysignificantdifference，thereisnorelationshipbetweenlevelofriskandthehistologicaltype．immunohistochemistry：CD17positivein81patient

6、s(93．1％)，73casesofCD34positive(83．9％)，17casewasSMApositive，11casesofS-100positive．Allpatientsunderwentsurgicalresection，65partialgastrectomy，16subtotalgastrectomy，5totalgastrectomy，lcombinedmultipleorgansresection．61patientswerefollowed-upfor8-50months(average34months)．Thepatientsofhigh—lowris

7、k，lowrisk，intermediaterisk，andhighriskwas7cases，12cases，21cases，and21cases，respectively．Comparedthetumordiameterofsurvivalgroupanddeathgroupinmedium—highriskpatients(accordingtothet，t=5．85，P