2型糖尿病患者糖耐量正常的一级亲属血浆srage水平相关因素的分析

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1、山求大学碰l：学位论文为园变量进行多元避步回归分析显示，BMI是血浆sRAGE的独立相关因素(复相关系数R。：0．145．P(O05)。3体质量指数jE常组和超重肥胖组m浆sRAGE的比较对阿组m浆sRAGE水平进行比较，超重肥胖组sRAGE水平明显低于体质量指数j下常组(尸<0．05)。结论：1．2型糖尿病的槠耐量正常一级亲属血浆中具有保护性作用的sRAGE水平明显低于正常人群，提示2型糖尿病的糖耐量正常一级亲属较_F常人群更容易罹患血管内皮损伤。2．sRAGE与BMI、WE、HC、WHR、FBG呈明显负相关，以上结论提示体重、腰臀围的增加血糖调节紊乱可能是导致sRAGE水平下降的重要参与者

2、。3BMI是血浆sRAGE的独立相关因素；sRAGE水平在超重肥胖组明显降低，提示体质量的增加是导致sRAGE水平下降的是重要因素。2型糖尿病一绒亲属的早期预防．应特别重视超重或肥胖现象．及时给予饮食、运动指导．减轻体质量．可能减少该人群在发生代谢紊乱时发生动脉功能受损的几率．为2型糖屎病血管并发症的一级预防做出贡献。关键词：sRAGE：2型糖尿病：糖耐量正常；一级亲属山东凡学碰I岸位论iStudyontheplasmaLevelofsRAGEandotherrelatedfactorsinfirst-degreerelativeswithnormalglucosetolerantofType

3、2DiabetesPostgraduateKangLeMajorEndocrinologyAdvisorProf．RellJianminAbstractohjec“ve：Advancedglycationendproducts(AGEs)anditsspecificreceptor(RAGE)areinvolvedinmanyvascularcomplications，theroleforthesolubleformofRAGE(sRAGE)，whichactsasadecoyforAGE，hasbeeninvestigatedandreportedalotinpatientswithdiab

4、etes，butlessinnon·diabeticespeciallythegroupoffirst-degreerelativesoftype2diabeteswithnormalglucosetoleranceInthisreseatch,WeinvestigatetheassociationbetweenplasmalevelsofthesolubleformofRAGE(sRAGE)andcardiometabolicriskfactorsinfirst-degreerelativesoftype2diabeteswlthnoma山glucosetoleranceMaterialsa

5、ndMethods：FromNov．．2010toJul．201Iindepartmentofendoednology，QiluHospital，ShandongUniversity82patientswithtype2diabetesmdlituswgi'℃enrolledinthegroupofproband，inwhichwefiltered51first-degreerelativeswithnormalglucosetolerance∞theobservationgroup．malein26c∞∞．femalein25cases。average40l±78years48healthy

6、personswithnohistoryofabnormalglucosetoleranceandlhmilyhistoryofdiabeteswereselected衄thecontrols，malein23cases，femalein25cases，average4343±I599yearsDiabetesdiagnosisisaccordingto1999WHOdiagnosticstandardofDMAllmembershadnoacutecomplication，cerebralinfarction，coronaryheartdisease,abnormalliverandrena

7、lfunctionortumoretcIJ来人学琐1j学位论史plasmalevelsofsRAGEweredetectedbyELISAin51first-degreerelativesoftype2diabeteswithnormalglucosetoleranceand48norraalcontrols，TheWC，HC，SUP,andDBPwe['emeasuredMeantime，oth