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1、-ABSTRACTgroupwas80%(36/45),higherthan58.1%(18/31)negativeexpressiongroup,2therewasstatisticallysignificantdifference(X=4.294,P<0.05);RASSF1proteinpositiveexpressionandesophagealcancerradiotherapyrecentcurativeeffectispositivelyrelatedtorelationship(r
2、=0.238,P=0.039).TheexpressionofCOX-2wascorrelatedwithradiosensitivityofESCC,butisnotindependentfactors.Fullsetofcompleteremission(CR)in41cases(53.9%)andpartialresponse(PR)in13(17.1%),SDfor18cases(23.7%),andPDfor4cases(5.1%).Theoverall1,2,3,4yearsofsur
3、vivalratesforESCCafterradiotherapywere62%,37%,18%,13%,andthemediansurialwas17months.UnivariateanalysisshowedthatTstaging,overallresponserate,RASSF1positiveexpressionandRASSF1positive+XRCC1negative（P=0.034,0.000,0.004,0.008）associatedwithprognosis.Whil
4、egender,age,tumorlocation,Nstage,clinicalstage,differentiationdegree,thelengthoflesion,COX-2expression,XRCC1expression,expressionofCOX-2andXRCC1andnegative,negative+RASSF1expresspositiveCOX-2expression,aswellasRASSF1positive+COX-2negative+XRCC1negativ
5、e,hasnoassociationwithradiationprognosis(P>0.05).MultivariateanalysisshowedthatoverallresponserateandRASSF1positiveexpressionradiationasindependentprognosticfactors(P=0.000and0.026),anditsassociatedORvalueswere3.724and2.065。.Conclusion:Theexpressionof
6、COX-2wascorrelatedwithradiosensitivityofESCC,butisnotindependentfactors.XRCC1proteinnegativeexpressionofoverallresponseratehigherefficientthanpositiveexpression,tosomeextenthintsXRCC1proteinnegativeexpressionofpatientsmaybenefitfromradiationtherapy.Po
7、sitiveexpressionofRASSF1associatedwithesophagealradiationsensitivity,isanindependentprognosticfactor.Thealleviateafterradicalradiotherapy,RASSF1positiveexpressionhasgoodprognosisofradiotherapy.KEYWORDS:esophagealneoplasms/radiotherapy;cyclooxygenase-2
8、(COX-2);X-rayrepaircrosscomplementinggroup1(XRCC1);rasassociationdomainfamily1(RASSF1);radiosensitivity;prognosisDissertationType:BasicresearchforapplicationVI万方数据ABSTRACTSubjectSource:scienceandtechnologyresearchprojectsofAnyangcity,Henanprov
