1025高渗盐水对缺血性脑水肿血脑屏障通透性影响的研究

1025高渗盐水对缺血性脑水肿血脑屏障通透性影响的研究

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时间:2019-02-03

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1、硕士学位论文P=0.975).Therewasintemctionbetweentreatmenttimesandtreatmentfactors(F=45.54,P=O.000).Tofurtheranalyzetheseparatedeffectsofthetreatmentfactors:atthedifferenttreatmenttimes,multiplecomparisonswereanalyzedbyLSDmethodifthedatawashomogeneityofvariance,otherwiseanaly

2、zedbyDunnett'sT3method.Comparedwithsham-operatedgroup,theBWCoftheperi-ischemicbraintissueWashigherinIschemiagroupandIO%HSgroup(P<0.01);ComparedwithIschemiagroup,theBWCinthe10%HSgroupWaslower(P<0.01).ThissuggestthatischemiahypoxiacatlleadtObrainedema,and10%HSintervent

3、ioncaneffectivelyrelievecerebraledema.2.ThecontentofEvansBlueintheperi—ischemicbraintissue:ThedifferenceofthecontentofEvansBlueintheperi—ischemicbraintissueWassignificantlydifferentamongthesham-operatedgroup,theIschemiagroupandthe10%HSgroup(F=351.702,P=0.000).Thecont

4、entofEvansBlueinIschemiagroupishigherthansham—operatedgroupand10%HSgroup,andthedifferenceofthecontentofEvansBlueintheischemichemispherewassignificantlystatisticalineachtreatmenttimes(F=3.428,P=0.041.Therewasinteractionbetweentreatmenttimesandtreatmentfactors(F=23.81,

5、P=0.ooo).Tofurtheranalyzetheseparatedeffectsofthetreatmentfactors:atthedifferemtreatmenttimes,multiplecomparisonswereanalyzedbyLSDmethodifthedatawashomogeneityofvariance,otherwiseanalyzedbyDunnett’ST3method.Comparedwithsham—operatedgroup,thecontentofEvansBlueoftheper

6、i-ischemicbraintissuewashigherinIschemiagroupand10%HSgroup(t’<0.01);Compared、~ithlschcmiagroup,thecontentofEvansBlueintheIO%HSgroupwaslower(P<0.01).ThissuggestthatischemiahypoxiaCanincreaseBBBpermeability,and10%HSinterventionCaneffectivelyreduceischemiahypoxiaBBBperm

7、eabilitycausedbyischemiahypoxia.3.TheexpressionofVEGFmRNAandproteinintheperi-isehemiebrainllABSTRACTtissue:OThedifferenceoftheexpressionofVEGFmRNAintheperi.ischemicbraintissuewassignificantlydifferentamongthesham—operatedgroup,theIschemiagroupandthe10%HSgroup(F=510.7

8、00,P=O.ooo).TheexpressionofVEGFmRNAishigherinIschemiagroupthaninsham-operatedgroupand10%HSgroup,andthedifferenceVEGFmRNAexpressioni

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