hfe基因多态性和乳腺癌、肝细胞癌、大肠癌发病风险meta分析

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1、ADissertationSubmittedtoHuazhongUniversityofScienceandTechnologyfortheDegreeofDoctorofMedicineHFEgenepolymorphismandBreastcancer、hepatocelluarcarcinomaandcolorectalCancer-Ameta-analysesPh.D.Candidate:HuijunHeMajor:ImmunologySupervisor:Prof.GuangxinShe

2、nHuazhongUniversityofScience&TechnologyWuhan430030,P.R.ChinaNov,2011独创性声明本人郑重声明，本学位论文是本人在导师指导下进行的研究工作及取得的研究成果的总结。尽我所知，除文中已经标明引用的内容外，本论文不包含任何其他个人或集体已经发表或撰写过的研究成果。对本文的研究做出贡献的个人和集体，均已在文中以明确方式标明。本人完全意识到本人将承担本声明引起的一切法律后果。学位论文作者签名：日期：年月日学位论文版权使用授权书本学位论文作者完全

3、了解学校有关保留、使用学位论文的规定，即：学校有权保留并向国家有关部门或机构送交论文的复印件和电子版，允许论文被查阅和借阅。本人授权华中科技大学可以将本学位论文的全部或部分内容编入有关数据库进行检索，可以采用影印、缩印或扫描等复制手段保存和汇编本学位论文。保密□，在_____年解密后适用本授权书。本论文属于不保密□。（请在以上方框内打―√‖）学位论文作者签名：指导教师签名：日期：年月日日期：年月日目录英文缩写词表（Abbreviations）····························

4、····················1前言·············································································4中文摘要···········································································11英文摘要·································································

5、··········14第一部分：HFE基因多态性与乳腺癌发病风险的Meta分析·········18第二部分：HFE基因多态性与肝癌发病风险的Meta分析············40第三部分：HFE基因多态性与大肠癌发病风险的Meta分析·········64小结·············································································87文献综述···································

6、········································88附录：在校期间发表论文及参与课题······································105致谢············································································106华中科技大学博士学位论文英文缩写词表（Abbreviations）缩略词英文全称中文全称δ-氨基乙酰丙酸合成酶ALAS2δ-aminolevu

7、linicacidsynthase22BMPbonemorphogeneticprotein成骨蛋白C/EBPCCAATenhancerbindingproteinC/EBPCIsConfidenceintervals可信区间CPceruloplasmin铜蓝蛋白DcytBDuodenalcytochromeB十二指肠细胞色素b二价金属离子转运体蛋DMTdivalentmetaltransporter白FPN1ferroportin铁转运蛋白FtMtmitochondrialferritin线粒体

8、铁蛋白FtFerritin铁蛋白felineleukemiavirussubgroupC猫白血病病毒亚组C细LVCRcellularreceptor胞受体HCChepatocelluarcarcinoma肝细胞癌HCP1hemecarrierprotein1血红素载体蛋白1遗传性血色病（蛋白）HFEhemochromatosis(protein)gene基因HHhereditaryhemochromatosis遗传性血色素沉着症1华中科技大学博士学位论文HIF-1αhypoxiai