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1、汕头大学医学院硕士学位论文功或院内死亡）例数多（1%vs4%，p=0.024）。多因素分析发现，女性（OR2.634[95%CI1.746-3.973]，p＜0.001）和年龄＞75岁（OR2.032[95%CI1.260-3.278]，p=0.004）是经桡动脉入路失败的独立预测因素。经桡动脉入路失败的原因包括：桡动脉穿刺失败34例（30%）、血管异常54例（47%）和导管导丝因素26例（23%）。结论：女性、年龄＞75岁是经桡动脉入路失败的独立危险因素。经桡动脉入路失败者冠脉左主干病变可能性更大。桡动脉入路失败的原因包括多方面
2、，其中血管异常为重要原因。临床工作中对行PCI的患者需要进行术前风险评估，从而选择合适的手术入路，进而提高经桡动脉入路PCI治疗的成功率。关键词：危险因素；经桡动脉入路；经皮冠状动脉介入术II汕头大学医学院硕士学位论文ABSTRACTObjectives：Thisretrospectivestudywasaimedtodeterminetherelatedriskfactorsofproceduralfailureinpatientsundergoingpercutaneouscoronaryintervention(PCI)fr
3、omthetransradialapproach(TRA)inthefirstaffiliatedhospitalofshantouuniversitymedicalcollege.Background:TransradialapproachPCIhavebeenshowntooffermanybenefitsovertransfemoralapproach,includingfewerbleedingandvascularcomplications,decreasedtimetoambulation,shorterlengtho
4、fhospitalstay,lowerhealthcarecosts.TRA-PCIfailurehasbeenreportedin5-10%ofcases.Reportedstudiesshowedthatage>75years,previousCABG,shortstature,femalesex,andcardiogenicshockwereindependentpredictorsofTRA-PCIfailure.However,relatedriskfactorsandcausesofTRA-PCIfailurearen
5、otwellcharacterized,especiallyamongAsians.Methods：WeretrospectivelyanalyzedourdatabasesforallpatientswhounderwentTRA-PCIfromJanuary2011toJune2014intheFirstAffiliatedHospitalofShantouUniversityMedicalCollege.Allthepatients’age,sex,hypertensionhistory,diabeteshistory,dy
6、slipidemia,renalinsufficiency,PCIhistory,smokinghistory,indicationforPCI,coronaryarteries,intervenedcoronaryartery,heparindose,fluoroscopytime,contrastvolume,GPIIb/IIIa,stents,proceduralfailure,and,ifany,reasonsforTRA-PCIfailurewereprospectivelycollected.Univariateand
7、multivariateanalyseswereperformedtodetermineindependentriskfactorsofTRA-PCIfailureandthecausesofTRA-PCIfailure.AllanalyseswereperformedwithSPSSversion19.0.ModifiedStudentttestwasusedforcomparisonofcontinuousdata,chi-squaretestwasusedforcomparisonofdichotomousdata.Step
8、wisemultiplelogisticregressionmodelswereusedtodeterminepredictorsofTRA-PCIfailure.Aprobabilityvalueof<0.05wasconsideredstati
