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1、广州医科大学硕士学位论文AntioxidantCarbocysteineTreatmentinObstructiveSleepApneaSyndromeAbstractObjectiveWeinvestigatethesymptoms,PSGparameters,oxidativestress,inflammatorymarkersandendothelialfunctionchangesbeforeandafterantioxidantscarbocisteinetreatmentinmoderatetosevereOSASpati
2、ents,inordertofindthevalueofantioxidantcarbocisteinetreatmentinOSASpatients.WehopethisstudycanprovidethebasisforantioxidanttreatmentinOSAS.MethodsMalepatientswererecruitedfromMarch2013toJanuary2014inFirstAffiliatedHospitalofGuangzhouMedicalUniversity,Guangzhouinstituteo
3、frespiratorydiseases.AllpatientswerediagnosedwithmoderatetosevereOSASbyPSG.Whenpatientsmettheinclusioncriteriaforthestudy,theywererandomlyassignedintotwogroups:onegroupwastreatedbycarbocisteine500mgtid.TheothergroupwastreatedbyAuto-CPAP.Beforeandafter6weekstreatment,all
4、patientswereundergoedadetailedquestionnaireandPSG,andbloodsampleswerecollectedinthenextmorning.1.TocomparethecomplianceoforalintakecarbocisteinetreatmentandCPAPtreatment.2.Toobservethedaytimeandnighttimesymptoms,apnea-hypopneaindex(AHI),oxygendesaturationindex(ODI),lowe
5、stoxygensaturation(LSaO2),meanoxygensaturation(MSaO2),timepercentageof90％oxygendesaturation（T90%）aswellasthesnoringparametersofthepeakfrequency(Fpeak),maximumfrequency(Fmax),meanfrequency(Fmean),mediumfrequency(Fmed),andoxidativestressbiomakerofmalondialdehyde(MDA),supe
6、roxidedismutase(SOD),glutathione(GSH)levelsinserum,andinflammatorybiomakerofinterleukin-64万方数据英文摘要(IL-6),seruminterleukin-8(IL-8)levelsinserum,andendothelialfunctionbiomakerofNO,endothelin-1(ET-1)levelsinserumbeforeandaftertreatmentoftwogroup.3.Toobserveendothelialfunct
7、ionbyultrasonographicmeasurementsofflow-mediateddilation(FMD)andcarotidarteryintima-mediathickness(IMT)beforeandaftercarbocisteinetreatment,correlationanalysisbetweenFMD,IMTandAHI,ODI,LSaO2,MSaO2,Fpeak,Fmax,Fmed,Fmean,MDA,SOD,GSH,IL-6,IL-8,NO,ET-1wasused.4.Tocomparepost
8、-treatment，after6weeksoftreatmentandthechangevaluebetweencarbocisteinegroupandCPAPgroupinESS,AHI,ODI,LSaO2,MSa
