人参皂苷rb1抑制自体静脉移植物内膜平滑肌细胞增生的分析

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1、AbstractResearchofGinsenosideRbloninhibitionofintimaIsmoothmusclecellhyperplasiainautologousveingraftsBackgroundand0bjectiveCoronaryarterybypassgraft(CABG)isoneofthemostimpritmanttreatmentofCoronaryAtheroscleroticHeartDisease(CAD)，thegreatsaphenousveinhasmanyadvantages，suchas：ithastherichsource，full

2、lengthandcanbeeasilyacquired，themostimportmentithasmajordiameterwhichisconducivetosuture，SinceFavalorothegreatsaphenousveinasgraftmaterial，ithasbecomethemajorclinicaltransplantmaterial．ButvariousmechanismcauseveingraftsrestenosisorocclusionwhichaffecststheservicelifeofveingraftsandreducesLong-termef

3、fect．Generallyspeaking，thelong-termpatencyrateofveingraftsisabout80％afteroneyear，75percentafterfiveyears，and50％aftwel0years，theannualocclusionrateis2-4％．Sosomepeoplehavetoaccepttherepeatedsurgery，andthepreventionofveingraftstenosisorocclusionhasbecomearesearchhotspot．GinsenosideRblisamonomercompound

4、extractedfromginseng，itisacalciumchannelblockerswhichcansignificantlyblockICa2+currentandreducerightventricularhypertrophy(RVl-1)whichcausedbymonocrataline(MCT)，italsocanresistarrhythmiaandtheinjuryofveingraftscausedbyhypoxic．Itisreportedthat：GinsenosideRblc柚inhibitthehyperplasiaofvascularsmoothmusc

5、lecells(VSMCs)byreduceProliferatingCellNuclearAntigen(PCNA)andTransformingGrowthFactor—beta，(TGFqB)geneexpressionintheprocessofneointimalhyperplasia，andthenreducethesynthesisandsecretionofextracellularmatrix(ECM)，inhibitintimalhyperplasiaandextendtheservicelifeoftheveingraft．TheexperimentwillEstabli

6、shtheanimalmodelinwhichtheexternaljugnlarveinofRabbitwillbecutandbesuturedtotheipsilateralcarotidartery，theniniectdosesofGinsenosideRblintraperitoneallytoobservethechangesofveingraftintimalthicknessandmorphologyaswellasPCNAandTGF—pgeneexpressioninthethreegroups．IVAbstractExploringtheeffectofginsenos

7、ideRbloninhibitionofrestenosisinveingraftsanditsmechanismofaction，andprovidingexperimentalandtheoreticalbasisforthefutu；'eclinicalapplicationsMaterialsandMethodsAtotalof45NewZealandrabbitswererandomly